modification — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T74550	Cemdisiran, terminal sugar modification-
	Cemdisiran, an investigational N-acetylgalactosamine-conjugated RNAi (RNA interference) agent with terminal sugar modification, is a small interfering RNA (siRNA) designed to specifically target and suppress the C5 mRNA,...
T13499	3-Methyluridine		Endogenous Metabolite
	3-Methyluridine is a modified nucleoside of cellular RNA.		Endogenous Metabolite
T16251	N-Succinimidyl-S-acetylthioacetate	SATA	Others
	N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent that introduces thiol-groups into protein molecules and adds sulfhydryl groups in a protected form to proteins and other amine-containing molecule...		Others
T3S2152	23-Hydroxybetulinic acid	Anemosapogenin	Others
	23-Hydroxybetulinic acid (Anemosapogenin) shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.		Others
T3532	5S rRNA modificator	FAI,Furoyl Acylimidazole	Others
	5S rRNA modificator (FAI), used in 5S rRNA RNA modification, is a suitable electrophile for 2'-hydroxyl acylation on structured RNA molecules.		Others
T39312	2-Hexylthiophene		Others
	2-Hexylthiophene, a weakly basic heteroaromatic compound, can enhance the molar absorption coefficient of ruthenium sensitizers by undergoing modification.		Others
T3725	K-Ras(G12C) Inhibitor 6		Raf
	K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro.		Raf
T0490	Chlorpropamide	Diabinese	ATPase , ABC
	Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.		ATPase , ABC
T1142	Clindamycin phosphate	Clindamycin 2-phosphate,Clindamycin 2-dihydrogen phosphate,NSC 618653,U-28508	ribosome , Antibacterial , Antibiotic , Parasite
	Clindamycin Phosphate is the phosphate salt form of clindamycin, a semi-synthetic, chlorinated broad-spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin phosphate (Clindamycin 2-dihydrogen ph...		ribosome , Antibacterial , Antibiotic , Parasite
T7949	NCC007		Casein Kinase
	NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.		Casein Kinase
T19210	Biotin LC hydrazide	Biotinamidocaproyl hydrazide,Biotin Aminocaproyl Hydrazide,(+)-Biotinamidohexanoic Acid hydrazide,BACH	Others
	Biotin LC hydrazide (BACH) is a modification reagent of long-chain protein. Biotin LC hydrazide transforms periodate-oxidized glycoproteins and can be used to target glycoproteins and glycans.		Others
T26296	Triparanol	MER-29,NSC 65345,NSC-65345,NSC65345	Apoptosis , Hedgehog/Smoothened
	Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparan...		Apoptosis , Hedgehog/Smoothened
T41286	N6-Isopentenyladenosine		Endogenous Metabolite , Autophagy
	N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/different...		Endogenous Metabolite , Autophagy
T8301	Amaranth	Acid Red 27	Others
	Amaranth (Acid Red 27) as a potential component of lifestyle modification to improve cardiovascular risk profiles by modifying cardiovascular risk factors such as cholesterol, diabetes, and hypertension.		Others
T6447	Clindamycin	Clinimycin,Sobelin,Chlolincocin	Antibacterial , Antibiotic
	Clindamycin (Sobelin) dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. Clindamycin is a semisynthetic broad-spectrum antibiotic produced by chemical modification of t...		Antibacterial , Antibiotic
T9808	Tetradecylthioacetic acid		PPAR
	Tetradecylthioacetic acid is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including acti...		PPAR
T6448	Clindamycin hydrochloride	Sobelin HCl,Cleocin,Clindamycin HCl,Clinimycin HCl	Antibacterial , Antibiotic
	Clindamycin hydrochloride (Clinimycin HCl) inhibits protein synthesis by acting on the 50S ribosomal. It is the hydrochloride salt form of clindamycin, a semi-synthetic, chlorinated broad-spectrum antibiotic produced by ...		Antibacterial , Antibiotic
T15735	Leptomycin B	CI 940,LMB	CRM1 , Antibiotic , Antifungal
	Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a ...		CRM1 , Antibiotic , Antifungal
T14080	AA147	ATF6-activator-147	Others
	AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially trigge...		Others
T5270	5-Methylcytosine		Others , DNA/RNA Synthesis , Endogenous Metabolite
	5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. In animals, the DNA methylation of cytosine to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In plants, the methylated...		Others , DNA/RNA Synthesis , Endogenous Metabolite