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MAPK Raf K-Ras(G12C) Inhibitor 6

K-Ras(G12C) Inhibitor 6

Catalog No. T3725   CAS 2060530-16-5

K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro.

K-Ras(G12C) Inhibitor 6, CAS 2060530-16-5
Pack Size Availability Price/USD Quantity
2 mg In stock 90.00
5 mg In stock 150.00
10 mg In stock 270.00
25 mg In stock 560.00
50 mg In stock 780.00
100 mg In stock 1090.00
1 mL * 10 mM (in DMSO) In stock 150.00
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Purity 98.00%
Purity 97.01%
Purity 100.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro.
Targets&IC50 K-Ras
Molecular Weight 405.33
Formula C17H22Cl2N2O3S
CAS No. 2060530-16-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 73 mg/mL (180.1 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Hunter JC, Gurbani D, Ficarro SB, Carrasco MA, Lim SM, Choi HG, Xie T, Marto JA, Chen Z, Gray NS, Westover KD. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8895-900. 2. Lim SM, Westover KD, Ficarro SB, Harrison RA, et al.Angew Chem Int Ed Engl. 2014 Jan 3;53(1):199-204. 3. Sakamoto K, Kamada Y, Sameshima T,et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):605-611.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Apoptosis Compound Library MAPK Inhibitor Library Kinase Inhibitor Library GPCR Compound Library Anti-cancer Metabolism Compound Library TGF-beta/Smad Compound Library Anti-obesity Compound Library HIF-1 Signaling Pathway Compound Library Covalent Inhibitor Library Anti-Pancreatic Cancer Compound Library Glutamine Metabolism Compound Library

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.