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Chlorpropamide

Catalog No. T0490   CAS 94-20-2
Synonyms: Diabinese

Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.

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Chlorpropamide Chemical Structure
Chlorpropamide, CAS 94-20-2
Pack Size Availability Price/USD Quantity
500 mg In stock $ 42.00
1 mL * 10 mM (in DMSO) In stock $ 46.00
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Purity: 99.01%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
In vivo At a concentration of 0.2 mM, chlorpropamide elevated the levels of fructose-2,6-bisphosphate (F-2,6-P2) in isolated hepatocytes from rats. The compound operates through a cyclic AMP-independent mechanism, enhancing insulin's inhibitory effect on glucagon-stimulated gluconeogenesis. Chlorpropamide significantly increased glucose metabolism and total lipid content, irrespective of insulin deficiency (30%) or presence (31%).
Kinase Assay Androgen Receptor Assay: Aliquots of 100 μl cytosol are incubated at 0-4°C for 18 h with 100 μl of the indicated saturating concentration of [3H]T in the presence or absence of increasing concentrations of nonlabeled T, DHT, flutamide (FLU) or flutamide-OH (FLU-OH). At the end of the incubation, free and bound T are separated by the addition of 200 μl dextran-coated charcoal (1 % charcoal, 0.1% dextran T-70, 0.1% gelatin, 1.5 mM EDTA and 50 mM Tris (pH 7.4)) for 15 min before centrifugation at 2300 × g for another 15 min at 0-4°C. Aliquots (350 μl) of the supernatant are transferred to scintillation vials with 10 ml of an aqueous counting solution before counting in a Beckman LS 330 counter.
Synonyms Diabinese
Molecular Weight 276.74
Formula C10H13ClN2O3S
CAS No. 94-20-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 51 mg/mL (184.3 mM)

DMSO: 51 mg/mL (184.3 mM)

TargetMolReferences and Literature

1. Monge L, et al. Diabetes, 1986, 35(1), 89-96. 2. Jacobs DB, et al. Metabolism, 1987, 36(6), 548-554. 3. Durr JA, et al. Am J Physiol Renal Physiol, 2000, 278(5), F799-808.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Human Metabolite Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Drug-induced Liver Injury (DILI) Compound Library ReFRAME Related Library Drug-Fragment Library Bioactive Compound Library Anti-Diabetic Compound Library

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Keywords

Chlorpropamide 94-20-2 Membrane transporter/Ion channel ATPase ABC Sodium potassium pump inhibit Na+/K+ ATPase Inhibitor Diabinese inhibitor

 

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