Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 42.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 46.00 |
Description | Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. |
In vivo | At a concentration of 0.2 mM, chlorpropamide elevated the levels of fructose-2,6-bisphosphate (F-2,6-P2) in isolated hepatocytes from rats. The compound operates through a cyclic AMP-independent mechanism, enhancing insulin's inhibitory effect on glucagon-stimulated gluconeogenesis. Chlorpropamide significantly increased glucose metabolism and total lipid content, irrespective of insulin deficiency (30%) or presence (31%). |
Kinase Assay | Androgen Receptor Assay: Aliquots of 100 μl cytosol are incubated at 0-4°C for 18 h with 100 μl of the indicated saturating concentration of [3H]T in the presence or absence of increasing concentrations of nonlabeled T, DHT, flutamide (FLU) or flutamide-OH (FLU-OH). At the end of the incubation, free and bound T are separated by the addition of 200 μl dextran-coated charcoal (1 % charcoal, 0.1% dextran T-70, 0.1% gelatin, 1.5 mM EDTA and 50 mM Tris (pH 7.4)) for 15 min before centrifugation at 2300 × g for another 15 min at 0-4°C. Aliquots (350 μl) of the supernatant are transferred to scintillation vials with 10 ml of an aqueous counting solution before counting in a Beckman LS 330 counter. |
Synonyms | Diabinese |
Molecular Weight | 276.74 |
Formula | C10H13ClN2O3S |
CAS No. | 94-20-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 51 mg/mL (184.3 mM)
DMSO: 51 mg/mL (184.3 mM)
You can also refer to dose conversion for different animals. More
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Chlorpropamide 94-20-2 Membrane transporter/Ion channel ATPase ABC Sodium potassium pump inhibit Na+/K+ ATPase Inhibitor Diabinese inhibitor