malignant — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8452	Dantrolene		Others
	Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.		Others
T22223	3PO		Glucokinase , Autophagy
	3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decrea...		Glucokinase , Autophagy
T2379	UNC1215		Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase
	UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold higher versus other members of the human MBT family.
T14214	AMG 511		PI3K
	AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG...		PI3K
T1973	PFI-4	PFI4	Epigenetic Reader Domain
	PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.		Epigenetic Reader Domain
TN2069	Picrocrocin		Apoptosis
	Picrocrocin is a natural product		Apoptosis
T9954	K-975		Others
	K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.		Others
T1120	Dacarbazine	Imidazole Carboxamide,DTIC-Dome	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.
T38050	CP-609754		Transferase
	CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 n...		Transferase
T21505	Suberoyl bis-hydroxamic acid	SBHA,Suberohydroxamic acid	Apoptosis , HDAC
	Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on ...		Apoptosis , HDAC
T16699	PYZD-4409		Others , E1/E2/E3 Enzyme
	PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.		Others , E1/E2/E3 Enzyme
TNU0123	5-Methoxyuridine	Mo5U	Apoptosis
	5-Methoxyuridine (Mo5U) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.5-Methoxyuridine's anticancer mechanism i...		Apoptosis
T76815	Lexatumumab	ETR2-ST01,DR5 mAB,HGS-ETR 2	Apoptosis
	Lexatumumab (GHS-ETR 2) is a human excitatory monoclonal antibody targeting TRAIL receptor 2 that has anticancer activity and induces apoptosis in malignant mesothelioma. Lexatumumab can be used to study malignant pleura...		Apoptosis
T67839	HG106		Others
	HG106, which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene., which is anti-inflammatory and may be used to treat the growth of diseases...		Others
T8762	SW106065	SW-106065	Apoptosis
	SW106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST). It inhibits ATP consumption...		Apoptosis
TNU0436	2-Thiocytidine		Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	2-Thiocytidine is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and has a broad spectrum of antitumor activity.2-Thiocytidine induces apoptosis by inhibiting DNA synthesis.2-Thioc...
T7491	6-O-Methyl Guanosine		Nucleoside Antimetabolite/Analog
	6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.		Nucleoside Antimetabolite/Analog
T8654	Plx-4032	Vemurafenib	Raf
	Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.		Raf
T77689	(1R,2R)-(-)-1,2-Diaminocyclohexane	(1R,2R)-Cyclohexane-1,2-diamin	Others
	(1R,2R)-(-)-1,2-Diaminocyclohexane ((1R,2R)-Cyclohexane-1,2-diamin) has anticancer and antitumor activity and can be used to study malignant tumors.		Others
T2068	(Rac)-LB-100		Phosphatase
	LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation		Phosphatase