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Plx-4032

Catalog No. T8654 CAS 1029872-54-5

Synonyms: Vemurafenib

Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Plx-4032, CAS 1029872-54-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 50.00
50 mg	In stock	$ 72.00
100 mg	In stock	$ 100.00
200 mg	In stock	$ 180.00
500 mg	In stock	$ 306.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.94%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
In vivo	PLX-4032 and its related analogs are highly potent inhibitors of B-Raf activity, with 3-fold selectivity for the V600E mutation over the wild-type kinase.?In preclinical models, PLX-4032 and its analogs inhibited the growth of BRAFV600E-positive melanoma cell lines both in vitro and in vivo[1].

Synonyms	Vemurafenib
Molecular Weight	489.92
Formula	C23H18ClF2N3O3S
CAS No.	1029872-54-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (61.23 mM)

References and Literature

1. Smalley K S M . PLX-4032, a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.[J]. Current Opinion in Investigational Drugs, 2010, 11(6):699-706. 2. Chapman, Paul, B, et al. Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation.[J]. New England Journal of Medicine, 2011.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Approved Drug Library Anti-Ovarian Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Colorectal Cancer Compound Library MAPK Inhibitor Library

Related Products

Related compounds with same targets

K-Ras(G12C) inhibitor 9 TBAP-001 Sulindac sulfide Locostatin B-Raf IN 16 BAY-293 BRAF inhibitor MRTX0902

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Plx-4032 1029872-54-5 MAPK Raf Vemurafenib Plx 4032 Plx4032 18504-65-1 inhibitor inhibit

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