lymphocytic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9925	Ofatumumab		Others
	Ofatumumab is a fully human monoclonal antibody to CD20 which appears to inhibit early-stage B lymphocyte activation		Others
T9744	MP07-66		Phosphatase
	MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.		Phosphatase
T12317	Orelabrutinib	ICP-022	BTK
	Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).		BTK
T3626	Acalabrutinib	ACP-196	BTK
	Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and pre...		BTK
T4976	Umbralisib	TGR-1202,RP5264,TGR 1202,TGR1202	PI3K
	Umbralisib (TGR 1202) is a PI3Kδ inhibitor.		PI3K
T2558	Cladribine	2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis , Adenosine deaminase
	Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.		Apoptosis , Adenosine deaminase
T16157	MT-802		BTK , PROTACs
	MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).		BTK , PROTACs
T15420	GS-9901		PI3K
	GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.		PI3K
T8380	Bendamustine	SDX105	Apoptosis , Others , DNA Alkylator/Crosslinker
	Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia		Apoptosis , Others , DNA Alkylator/Crosslinker
TP1758L	LCMV gp33-41 acetate	LCMV gp33-41 acetate（151705-84-9 Free base）	Others
	LCMV gp33-41 acetate is a sequence of lymphocytic choriomeningitis virus which restricted by major histocompatibility complex class I H-2Db and presented to cytotoxic T lymphocytes.		Others
T77093	Theralizumab	TGN1412,TAB-08,TABO8	Others
	Theralizumab (TGN1412) is an anti-CD28-targeting monoclonal antibody that directly stimulates T cells. Theralizumab has antitumor activity and is used for the treatment of B-cell chronic lymphocytic leukemia and rheumato...		Others
T3099	Pinometostat	EPZ-5676	Histone Methyltransferase
	Pinometostat (EPZ-5676) has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leukemia, among others.		Histone Methyltransferase
T76794	Ulocuplumab	BMS 936564,MDX 1338	Apoptosis , CXCR
	Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplu...		Apoptosis , CXCR
T38622	Bcl-xL antagonist 2		BCL
	Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic l...		BCL
T4564	Ethacrynic acid	Edecrin,Etacrynic Acid,Hydromedin	Others , Calcium Channel , NF-κB , GST
	Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase a...		Others , Calcium Channel , NF-κB , GST
T10483	Lisaftoclax	Bcl-2/Bcl-xl inhibitor 1,APG-2575	BCL
	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL...		BCL
T19661	8-Chloroadenosine	NSC 354258,8-Cl-Ado,NSC354258,NSC-354258	AMPK
	8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch...		AMPK
TP1758	LCMV gp33-41
	LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes.This is the H-2Db restricted ep...
T71996	VU0621623
	VU0621623 is an arenavirus multiplication inhibitor which blocks lymphocytic choriomeningitis virus (LCMV) cell entry.
TP1640	Glycoprotein (276-286)	Glycoprotein 276-286
	Known Db-restricted peptide of lymphocytic choriomeningitis virus (LCMV).