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Lisaftoclax

Catalog No. T10483   CAS 2180923-05-9
Synonyms: Bcl-2/Bcl-xl inhibitor 1, APG-2575

Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.

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Lisaftoclax Chemical Structure
Lisaftoclax, CAS 2180923-05-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 313.00
5 mg In stock $ 690.00
10 mg In stock $ 992.00
25 mg In stock $ 1,470.00
50 mg In stock $ 1,980.00
100 mg In stock $ 2,680.00
1 mL * 10 mM (in DMSO) In stock $ 981.00
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Purity: 98.22%
Purity: 97.14%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.
Targets&IC50 BCL-XL:5.9 nM, BCL2:2 nM
In vitro Lisaftoclax shows IC50s of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4 11 cells and Bcl-xl dependent Molm 13 cells[1].
Synonyms Bcl-2/Bcl-xl inhibitor 1, APG-2575
Molecular Weight 882.42
Formula C45H48ClN7O8S
CAS No. 2180923-05-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (51 mM), Sonication is recommended.

TargetMolReferences and Literature

1. WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Active Compound Library PPI Inhibitor Library Bioactive Compound Library Clinical Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max

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Keywords

Lisaftoclax 2180923-05-9 Apoptosis BCL APG2575 APG 2575 Bcl-2/Bcl-xl inhibitor 1 APG-2575 inhibitor inhibit

 

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