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Lisaftoclax

Catalog No. T10483 CAS 2180923-05-9

Synonyms: APG-2575, Bcl-2/Bcl-xl inhibitor 1

Lisaftoclax is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.

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Lisaftoclax, CAS 2180923-05-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 342.00
5 mg	In stock	$ 765.00
10 mg	In stock	$ 1,215.00

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Purity: 98.22%

Purity: 97.14%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lisaftoclax is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.
Targets&IC50	Bcl-xL:5.9 nM, Bcl-2:2 nM
In vitro	Lisaftoclax shows IC50s of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4 11 cells and Bcl-xl dependent Molm 13 cells[1].

Synonyms	APG-2575, Bcl-2/Bcl-xl inhibitor 1
Molecular Weight	882.42
Formula	C45H48ClN7O8S
CAS No.	2180923-05-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 225mg/mL (255mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Bioactive Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library

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Keywords

Lisaftoclax 2180923-05-9 Apoptosis BCL APG-2575 Bcl-2/Bcl-xl inhibitor 1 Inhibitor inhibitor inhibit

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