impairments — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22012	7BIO		FLT , DYRK , Aurora Kinase
	7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.		FLT , DYRK , Aurora Kinase
T0185	Escitalopram	Seroplex,S-(+)-Citalopram,(S)-Citalopram	Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
	Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patien...
T6493	Escitalopram Oxalate	Cipralex,(S)-(+)Citalopram oxalate	Others , 5-HT Receptor , Serotonin Transporter
	Escitalopram Oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.		Others , 5-HT Receptor , Serotonin Transporter
T7114	GALANTHAMINONE	(-)-Narwedine,Narwedin	AChE
	Galanthaminone ((-)-Narwedine) is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.		AChE
T1128	Oxiracetam	ISF2522	GABA Receptor
	Oxiracetam (ISF2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is utilized for the treatment of cognitive impairments.		GABA Receptor
T7165	Basmisanil	RG1662,RO5186582	GABA Receptor
	Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro...		GABA Receptor
T14507	Bay 60-7550	BAY 607550	PDE
	Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and mem...		PDE
T16518	PH-002		Others
	PH-002, an inhibitor targeting the intramolecular domain interaction of apolipoprotein (apo) E4 in neuronal cells, additionally enhances mitochondrial motility and promotes neurite outgrowth, thereby countering related i...		Others
T14782	Brilaroxazine	RP5063	Dopamine Receptor , 5-HT Receptor
	Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...		Dopamine Receptor , 5-HT Receptor
T26646	AQW051	AQ W051,VQW-765,AQW-051	AChR
	AQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attrac...		AChR
T25005	AF267	(±)AF 267,(±) AF 267,(±)-AF 267,AF 267,AF-267
	AF267 is a M1 muscarinic agonist that works by restoring cognitive impairments.
T68377	GRL-8234
	GRL-8234 is a small-molecule BACE1 inhibitor that reverses memory impairments and age-related cognitive decline.
T61258	HFI-419
	HFI-419 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) with a K i value of 0.48 μM. It is utilized in research pertaining to cognitive and memory impairments, including Alzheimer's disease, brain trauma...
T82725	Chrysanthellin A
	Chrysanthellin A, the principal saponin-derived compound isolated from Chrysanthellum americanum extract, is utilized in the research of digestive impairments [1].
T61342	BChE-IN-13
	BChE-IN-13 (Compound 17c) is an orally active, potent, and selective inhibitor of Butyrylcholinesterase (BChE). It exhibits IC50 values of 0.22 μM and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 demonstrates ...
T61669	BChE-IN-4
	BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic a...
T70075	KDS2010 mesylate
	KDS2010 is a potent, highly selective, and reversible MAO-B inhibitor which shows 12,500-fold selectivity over MAO-A. KDS2010 overcomes the disadvantages of the irreversible MAO-B inhibitor and significantly attenuates i...
T78171	QR-0217
	QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40. Additionally, QR-0217 has been shown to alleviate memory impairments attributed to Aβ neurotoxicity [1].
T33766	OAB-14	OAB 14,OAB14
	OAB-14 is a Bexarotene derivative that improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the e...
T39421	DSR-141562
	DSR-141562 is a new compound that can be taken orally and has a specific ability to inhibit phosphodiesterase 1 (PDE1) in the brain. This compound exhibits a preference for inhibiting human PDE1B, with an IC50 value of 4...