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AQW051

Catalog No. T26646 CAS 669770-29-0

Synonyms: AQ W051, VQW-765, AQW-051

AQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attractive target for the treatment of cognitive impairments associated with neurological disorders, so VQW-051 is often used in studies of anxiety disorders and acute anxiety.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AQW051, CAS 669770-29-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 139.00
25 mg	In stock	$ 289.00
50 mg	In stock	$ 455.00
100 mg	In stock	$ 672.00
500 mg	In stock	$ 1,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attractive target for the treatment of cognitive impairments associated with neurological disorders, so VQW-051 is often used in studies of anxiety disorders and acute anxiety.
Targets&IC50	α7 nAChR:7.41(pEC50)
In vitro	AQW-051 binds to recombinant human α7-nACh receptor with a pKD value of 7.56. AQW051 effectively activated the calcium transient in GH3-ha7-22 cells stimulated by recombinant expression of α7-nACh receptor, with a pEC50 value of 7.41[1].
In vivo	Mice administered orally with AQW051 at 0.03 and 0.3 mg/kg enhances cognitive effects and learning/memory performance. Orally AQW051 1mg/kg each time in rats increasing the social exploration time, demonstrating the antianxiety effect of AQW051[1].

Synonyms	AQ W051, VQW-765, AQW-051
Molecular Weight	294.39
Formula	C19H22N2O
CAS No.	669770-29-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.4 mg/mL (14.95 mM)

References and Literature

1. Barch DM, et al. Task-related fMRI responses to a nicotinic acetylcholine receptor partial agonist in schizophrenia: A randomized trial. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:66-75. 2. Welsh KJ, Bai Y; Education Committee of the Academy of Clinical Laboratory Physicians and Scientists. Pathology Consultation on Patients With a Large Rh Immune Globulin Dose Requirement. Am J Clin Pathol. 2016 Jun;145(6):744-51. 3. Trenkwalder C,et al. A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia. Mov Disord. 2016 Jul;31(7):1049-54. 4. Beinat C, et al. The therapeutic potential of α7 nicotinic acetylcholine receptor (α7 nAChR) agonists for the treatment of the cognitive deficits associated with schizophrenia. CNS Drugs. 2015 Jul;29(7):529-42.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library Clinical Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AQW051 669770-29-0 Neuroscience AChR AQ W051 AQ W 051 VQW765 AQW 051 VQW 765 VQW-765 AQW-051 AQ W-051 inhibitor inhibit

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