hypoxic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2423	P7C3-A20		Others
	P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.		Others
T2046	Nimorazole	Nimorazol,Nitrimidazine,K-1900,Naxogin	Others , Antibiotic , Parasite
	Nimorazole (Nimorazol) is a nitroimidazole anti-infective.		Others , Antibiotic , Parasite
T10459	Banoxantrone dihydrochloride	AQ4N dihydrochloride,AZD1689 2HCl	NOS
	Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel hypoxic cytotoxin that selectively kills hypoxic cells through an iNOS-dependent mechanism.		NOS
T67963	Teniloxazine
	Teniloxazine is an orally available antidepressant compound with anti-hypoxic properties.
T2020	RGW 611		Others
	RGW 611 is a morpholine derivative that enhances radiation and induces cell death in hypoxic V79-379A cells.		Others
TN1916	Matairesinol		ATPase , p38 MAPK , ROS
	Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.		ATPase , p38 MAPK , ROS
T28607	Rocepafant	LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730	Platelet aggregation
	Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor...		Platelet aggregation
T0294	6α-Methylprednisolone 21-hemisuccinate sodium salt	Asmacortone,Methylprodnisolone Sodium Succinate,Metypresol,Methylprednisolone sodium succinate,Corticel,6-Methylprednisolone succinate sodium	Glucocorticoid Receptor , Glucagon Receptor
	6α-Methylprednisolone 21-hemisuccinate sodium salt (Asmacortone), a water-soluble ester, is used for allergic, cardiac, and hypoxic emergencies.		Glucocorticoid Receptor , Glucagon Receptor
T3615	Evofosfamide	TH-302	Apoptosis , Others
	Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed to hypoxic conditions, ...		Apoptosis , Others
T11244	Etimizol	Ethymisol,Ethimizole,Ethymisole	Others
	Etimizol (Ethimizole) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). The positive effect of Etimizol on ...		Others
TQ0121	VH-298		Others , HIF , Ligand for E3 Ligase
	VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by P...		Others , HIF , Ligand for E3 Ligase
T5773	Moslosooflavone	5-hydroxy-7,8-dimethoxyflavone	NF-κB , Reactive Oxygen Species
	Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activi...		NF-κB , Reactive Oxygen Species
T67291	2′,2′-Difluorodeoxyuridine	dFdU,2',2'-Difluoro-2'-deoxyuridine	Drug Metabolite
	2′,2′-Difluorodeoxyuridine (dFdU) is the major metabolite of Gemcitabine.2′,2′-Difluorodeoxyuridine has anticancer and antitumor activity, and shows radiosensitization under hypoxic conditions, and can be used to study p...		Drug Metabolite
T21494	Oligomycin		HIF
	Oligomycin is an antifungal antibiotic that is an inhibitor of H+-ATP synthetase. The Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibited HIF-1alpha expression in hypoxic tu...		HIF
T4434	Tirapazamine	Tirazone,Win59075,SR4233,SR259075	Others
	Tirapazamine (Win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to oth...		Others
T16537	Pimonidazole		Others
	Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of...		Others
T16536	Pimonidazole hydrochloride
	Pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative...
TP1886L1	NoxA1ds acetate(1435893-78-9 free base)		NADPH-oxidase
	NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col...		NADPH-oxidase
T2S0843	Negletein	7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor , TNF , NOS , Interleukin
	1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n...		IL Receptor , TNF , NOS , Interleukin
T21270	Isometronidazole	R.P. 8979,Isometronidazole, Izoklion
	Isometronidazole is a hypoxic cell sensitizer.