directly — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15247	ESI-05	NSC 116966	cAMP
	ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.		cAMP
T0373	Erlotinib	OSI-744,NSC 718781,CP358774,R1415	EGFR , Autophagy
	Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.		EGFR , Autophagy
T23401	Strontium chloride		Others , CaSR
	Strontium chloride is an agonist of Calcium sensing receptor (CaSR) and directly affects C-type nerve fibers.		Others , CaSR
T9734	InhA-IN-2		CDK
	InhA-IN-2 directly inhibits InhA and does not require activation by the catalase peroxidase KatG.		CDK
T37562	C16 Ceramide	N-acylsphingosine,C16 Ceramide (d18:1/16:0),Palmitoyl Ceramide,N-Palmitoylsphingosine	p53
	C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.		p53
TP2307	Pinealon Acetate		Others
	Pinealon Acetategland has antioxidant activity and can directly interact with the cell genome.		Others
T24729	Roseoflavin		Antibacterial
	Roseoflavin, a chemical analog of FMN and riboflavin that has antimicrobial activity, can directly bind to FMN riboswitch aptamers and downregulate the expression of an FMN riboswitch-lacZ reporter gene in B. subtilis.		Antibacterial
T26408	A 21960	Ethyl 2-chloroacetoacetate,A21960,A-21960
	A 21960 (Ethyl 2-chloroacetoacetate) inhibits synapse formation between resolvase and two directly repeated res sites, blocks site-specific recombination reactions, and can be used to study bacterial infections.
T1494	Alarelin Acetate	Alarelin	GNRH Receptor
	Alarelin Acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors.		GNRH Receptor
T2450	SANT-1	SANT 1	Hedgehog/Smoothened , Smo
	SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).		Hedgehog/Smoothened , Smo
T12478L	Pinacidil	S 1230,P 1134,S-1230,P-1134,P1134	Potassium Channel
	Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention.		Potassium Channel
T11986L	Mebeverine acid hydrochloride
	Mebeverine acid hydrochloride is an effective, oral compound to act directly on the smooth muscle of the gastrointestinal tract to relieve spasticity symptoms.
T12616L	CE3F4		cAMP
	CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1; IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively).		cAMP
T38563	Raptinal		Caspase
	Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.		Caspase
T60051	VPC-18005		Others
	VPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.		Others
T11666	IPR-803		Serine/threonin kinase
	IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM.		Serine/threonin kinase
T1810	Purmorphamine	Shh Signaling Antagonist VI	Hedgehog/Smoothened , Smo , Autophagy
	Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.		Hedgehog/Smoothened , Smo , Autophagy
T14848	C 87		Others , TNF
	C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.		Others , TNF
T6762	AS1842856		Autophagy , FOXO1
	AS1842856, a cell-permeable inhibitor, can block the transcription activity of Foxo1 (IC50: 33 nM). It can directly bind to the active Foxo1, but not the Ser256-phosphorylated form.		Autophagy , FOXO1
T8874	FB23		Others
	FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.)		Others