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AS1842856

Catalog No. T6762   CAS 836620-48-5

AS1842856, a cell-permeable inhibitor, can block the transcription activity of Foxo1 (IC50: 33 nM). It can directly bind to the active Foxo1, but not the Ser256-phosphorylated form.

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AS1842856 Chemical Structure
AS1842856, CAS 836620-48-5
Pack Size Availability Price/USD Quantity
5 mg In stock $ 47.00
10 mg In stock $ 67.00
25 mg In stock $ 109.00
50 mg In stock $ 155.00
100 mg In stock $ 238.00
200 mg In stock $ 352.00
500 mg In stock $ 595.00
1 mL * 10 mM (in DMSO) In stock $ 52.00
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Purity: 100%
Purity: 99.56%
Purity: 99.54%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AS1842856, a cell-permeable inhibitor, can block the transcription activity of Foxo1 (IC50: 33 nM). It can directly bind to the active Foxo1, but not the Ser256-phosphorylated form.
Targets&IC50 Foxo1:33nM
In vitro AS1842856 predominantly suppresses Foxo1-mediated transactivation by directly binding to Foxo1. In HepG2 cells transiently transfected with a Foxo1 expression vector, AS1842856 potently represses Foxo1-mediated promoter activity in a dose-dependent manner similar to that seen in insulin treatment.AS1842856 administered at 0.1 μM inhibits Foxo3a- and Foxo4-mediated promoter activity by 3 and 20%, respectively. In contrast, Foxo1-mediated promoter activity is decreased by 70%. Foxo1 inhibitor AS1842856 may suppress endogenous G6Pase and PEPCK activities by decreasing their mRNA levels, which may lead to inhibition of glucose production in Fao cells[1].
In vivo Oral administration of AS1842856 to diabetic db/db mice leads to a drastic decrease in fasting plasma glucose level via the inhibition of hepatic gluconeogenic genes while administration to normal mice does not affect on the fasting plasma glucose level. Treatment with AS1842856 also suppresses an increase in plasma glucose level caused by pyruvate injection in both normal and db/db mice[1].
Cell Research Fao cells are serum-starved (1 h) and incubated for 30 min with either insulin or AS1842856 at the indicated concentration. Protein lysates are prepared from cells treated with either insulin or AS1842856, and relative concentration of phosphorylated Foxo1 protein is determined by Western blot analysis. (Only for Reference)
Molecular Weight 347.38
Formula C18H22FN3O3
CAS No. 836620-48-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7 mg/mL(20.2 mM)

Ethanol: <1 mg/mL

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Takeyuki Nagashima,et al.Mol Pharmacol.2010,78(5):961-970. 2. Peng Zou, et al. Cell Cycle. 2014 Dec 1; 13(23): 3759–3767.

TargetMolCitations

1. Lu Y, Huang R, Sun Z, et al.A bovine milk-derived peptide ameliorates pancreatic β-cell dedifferentiation through PI3K/Akt/FOXO1 signaling in type 2 diabetes.Food & Function.2023

Related compound libraries

This product is contained In the following compound libraries:
Fluorochemical Library Transcription Factor-Targeted Compound Library Bioactive Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Apoptosis Compound Library Immunology/Inflammation Compound Library Autophagy Compound Library Inhibitor Library

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Keywords

AS1842856 836620-48-5 Apoptosis Autophagy FOXO1 AS 1842856 inhibit AS-1842856 Inhibitor inhibitor

 

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