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AS1842856

Catalog No. T6762 CAS 836620-48-5

AS1842856, a cell-permeable inhibitor, can block the transcription activity of Foxo1 (IC50: 33 nM). It can directly bind to the active Foxo1, but not the Ser256-phosphorylated form.

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AS1842856, CAS 836620-48-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 67.00
25 mg	In stock	$ 109.00
50 mg	In stock	$ 155.00
100 mg	In stock	$ 238.00
200 mg	In stock	$ 352.00
500 mg	In stock	$ 595.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 100%

Purity: 99.56%

Purity: 99.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AS1842856, a cell-permeable inhibitor, can block the transcription activity of Foxo1 (IC50: 33 nM). It can directly bind to the active Foxo1, but not the Ser256-phosphorylated form.
Targets&IC50	FOXO1:33nM
In vitro	AS1842856 predominantly suppresses Foxo1-mediated transactivation by directly binding to Foxo1. In HepG2 cells transiently transfected with a Foxo1 expression vector, AS1842856 potently represses Foxo1-mediated promoter activity in a dose-dependent manner similar to that seen in insulin treatment.AS1842856 administered at 0.1 μM inhibits Foxo3a- and Foxo4-mediated promoter activity by 3 and 20%, respectively. In contrast, Foxo1-mediated promoter activity is decreased by 70%. Foxo1 inhibitor AS1842856 may suppress endogenous G6Pase and PEPCK activities by decreasing their mRNA levels, which may lead to inhibition of glucose production in Fao cells[1].
In vivo	Administering AS1842856 orally to diabetic db/db mice significantly reduces the fasting plasma glucose levels by suppressing hepatic gluconeogenic genes. However, this compound does not alter fasting plasma glucose levels in normal mice. Additionally, AS1842856 prevents the rise in plasma glucose levels following pyruvate injection in both normal and db/db mice[1].
Cell Research	Fao cells are serum-starved (1 h) and incubated for 30 min with either insulin or AS1842856 at the indicated concentration. Protein lysates are prepared from cells treated with either insulin or AS1842856, and relative concentration of phosphorylated Foxo1 protein is determined by Western blot analysis. (Only for Reference)

Molecular Weight	347.38
Formula	C18H22FN3O3
CAS No.	836620-48-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.47 mg/mL (10 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Takeyuki Nagashima,et al.Mol Pharmacol.2010,78(5):961-970. 2. Peng Zou, et al. Cell Cycle. 2014 Dec 1; 13(23): 3759–3767.

Citations

1. Lu Y, Huang R, Sun Z, et al.A bovine milk-derived peptide ameliorates pancreatic β-cell dedifferentiation through PI3K/Akt/FOXO1 signaling in type 2 diabetes.Food & Function.2023

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Fluorochemical Library Autophagy Compound Library Apoptosis Compound Library Bioactive Compound Library Transcription Factor-Targeted Compound Library NO PAINS Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max

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Keywords

AS1842856 836620-48-5 Apoptosis Autophagy FOXO1 AS 1842856 inhibit AS-1842856 Inhibitor inhibitor

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