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ESI-05

🥰Excellent
Catalog No. T15247Cas No. 5184-64-5
Alias NSC 116966

ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.

ESI-05

ESI-05

🥰Excellent
Purity: 97.22%
Catalog No. T15247Alias NSC 116966Cas No. 5184-64-5
ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$33In StockIn Stock
5 mg$52In StockIn Stock
10 mg$94In StockIn Stock
25 mg$169In StockIn Stock
50 mg$285In StockIn Stock
100 mg$487In StockIn Stock
1 mL x 10 mM (in DMSO)$58In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:97.22%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.
Targets&IC50
EPAC2:0.4 μM
SynonymsNSC 116966
Chemical Properties
Molecular Weight274.38
FormulaC16H18O2S
Cas No.5184-64-5
SmilesCc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C
Relative Density.1.129 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 83.33 mg/mL (303.7 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 3.3 mg/mL (12.03 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6446 mL18.2229 mL36.4458 mL182.2290 mL
5 mM0.7289 mL3.6446 mL7.2892 mL36.4458 mL
10 mM0.3645 mL1.8223 mL3.6446 mL18.2229 mL
20 mM0.1822 mL0.9111 mL1.8223 mL9.1115 mL
50 mM0.0729 mL0.3645 mL0.7289 mL3.6446 mL
100 mM0.0364 mL0.1822 mL0.3645 mL1.8223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NSC-116966NSC116966neurological disordersmono- acylglycerol acyltransferaseIntracranial hemorrhage (ICH)insulin secretionInhibitorinhibitGEFexchange proteins directly activated by cAMP 2 (EPAC2)ESI-05ESI05ESI 05EPAC2Diglyceride acyltransferaseDiacylglycerol acyltransferasediabetescAMPAcyltransferaseacyl-CoA:cholesterol acyltransferase
Related Tags: buy ESI-05 | purchase ESI-05 | ESI-05 cost | order ESI-05 | ESI-05 chemical structure | ESI-05 formula | ESI-05 molecular weight
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