store at low temperture,keep away from moisture
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Alarelin acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors.
Description | Alarelin acetate is a synthetic GnRH agonist which can directly inhibit proliferation and DNA synthesis of rat GSMC through GnRH receptors. |
In vitro | The cell viability in the presence of alarelin was significantly lower compared to in the absence of alarelin. The maximum stimulatory effect on cell viability was achieved at a concentration of 10-5 M and it acted in a dose-dependent manner[1]. |
In vivo | Alarelin could inhibit the gastric acid secretion both by direct actions on parietal cells in rats and by inhibiting vagous function[2]. Alarelin could markedly increase the ratio of G1 phase and decrease ratio of S phase of GSMC of rats[1]. |
Cell Research | The cells are trypsinized in a solution of 2.5 g/L trypsin and seeded in a 96-well plate. After the cells are grown for 24 h to approximately 800 g/L subconfluent state, 0.1 mL medium containing 2.5% calf serum and various concentrations (0.001, 0.1, 10 μM) of alarelin is added to each well, respectively, and incubated for 24 h in a CO2 incubator. Each concentration is tested in at least 12 wells. Briefly, 15 μL of MTT solution is added to each well and incubated for 4 h. Then, the medium and MTT are removed and 150 μL of DMSO is added to each well and shaken for 10 min to dissolve the crystal. The OD is determined at 490 nm using an ELISA reader[1]. |
Synonyms | Alarelin |
Molecular Weight | 1167.34 |
Formula | C56H78N16O12 |
CAS No. | 79561-22-1 |
store at low temperture,keep away from moisture
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 58 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Alarelin Acetate 79561-22-1 GPCR/G Protein GNRH Receptor GnRH Receptor Inhibitor Gonadotropin releasing hormone receptor inhibit GNRHR Alarelin inhibitor