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Search Results for " depressive "

20

Compounds

Cat No. Product Name Synonyms Targets
T20993 Memantine Others
Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by ...
T7061 Duloxetine Serotonin Transporter
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.
T21635 PD184161 MEK
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].
T16481 PF-04995274 5-HT Receptor
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a...
T15799 LY2940094 LY-2940094 Opioid Receptor
LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist pot...
T14782 Brilaroxazine RP5063 Dopamine Receptor , 5-HT Receptor
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...
T7805 GW791343 dihydrochloride GW791343 (HCl) P2X Receptor
GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.
T3933 Jatrorrhizine Yatrorizine,neprotin MAO , 5-HT Receptor , Antibacterial , AChE
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo...
T1279 Vilazodone SB659746A,EMD 68843 5-HT Receptor , Serotonin Transporter
Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from...
T1445 Agomelatine Thymanax,S-20098,Valdoxan Melatonin Receptor , 5-HT Receptor
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
T4912 Jatrorrhizine chloride Yatrorhizine chloride,Neprotine chloride Others , 5-HT Receptor , OCT , Antibacterial , AChE
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...
T5135 Flupentixol dihydrochloride Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride Dopamine Receptor
Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.
T1471 Duloxetine hydrochloride Duloxetine HCl,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and i...
T6526 GW791343 trihydrochloride GW791343 3HCl P2X Receptor
GW791343 trihydrochloride (GW791343 3HCl) is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
T1619 Trazodone hydrochloride KB-831,Trazodone HCl,AF-1161 5-HT Receptor , Adrenergic Receptor , Histamine Receptor
Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressi...
T0338 Minaprine Cantor,Minaprine dihydrochloride,Minaprina,Minaprinum MAO , Dopamine Receptor , 5-HT Receptor , AChR , AChE , Monoamine Oxidase
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T27599 Imiloxan RS-21361,RS 21361,RS21361 Adrenergic Receptor
Imiloxan (RS-21361) is an α2 adrenergic receptor antagonist used in the treatment of major depressive disorder.
T10075 2-Methyl-5-HT 2-Methyl-5-hydroxytryptamine 5-HT Receptor
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
T68172 Zalospirone 5-HT Receptor
Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder.
T32737 Liafensine BMS820836,BMS 820836,DB104,BMS-820836 Dopamine Receptor , 5-HT Receptor , Norepinephrine
Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and centra...

Compounds

Memantine
T20993
Synonym:
Target: Others
Duloxetine
T7061
Synonym:
Target: Serotonin Transporter
PD184161
T21635
Synonym:
Target: MEK
PF-04995274
T16481
Synonym:
Target: 5-HT Receptor
LY2940094
T15799
Synonym: LY-2940094
Target: Opioid Receptor
Brilaroxazine
T14782
Synonym: RP5063
Target: Dopamine Receptor, 5-HT Receptor
GW791343 dihydrochloride
T7805
Synonym: GW791343 (HCl)
Target: P2X Receptor
Jatrorrhizine
T3933
Synonym: Yatrorizine,neprotin
Target: MAO, 5-HT Receptor, Antibacterial, AChE
Vilazodone
T1279
Synonym: SB659746A,EMD 68843
Target: 5-HT Receptor, Serotonin Transporter
Agomelatine
T1445
Synonym: Thymanax,S-20098,Valdoxan
Target: Melatonin Receptor, 5-HT Receptor
Jatrorrhizine chloride
T4912
Synonym: Yatrorhizine chloride,Neprotine chloride
Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE
Flupentixol dihydrochloride
T5135
Synonym: Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride
Target: Dopamine Receptor
Duloxetine hydrochloride
T1471
Synonym: Duloxetine HCl,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl
Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine
GW791343 trihydrochloride
T6526
Synonym: GW791343 3HCl
Target: P2X Receptor
Trazodone hydrochloride
T1619
Synonym: KB-831,Trazodone HCl,AF-1161
Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor
Minaprine
T0338
Synonym: Cantor,Minaprine dihydrochloride,Minaprina,Minaprinum
Target: MAO, Dopamine Receptor, 5-HT Receptor, AChR, AChE, Monoamine Oxidase
Imiloxan
T27599
Synonym: RS-21361,RS 21361,RS21361
Target: Adrenergic Receptor
2-Methyl-5-HT
T10075
Synonym: 2-Methyl-5-hydroxytryptamine
Target: 5-HT Receptor
Zalospirone
T68172
Synonym:
Target: 5-HT Receptor
Liafensine
T32737
Synonym: BMS820836,BMS 820836,DB104,BMS-820836
Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine
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TargetMol