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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T20993 | Memantine | Others | |
Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by ... | |||
T7061 | Duloxetine | Serotonin Transporter | |
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder. | |||
T21635 | PD184161 | MEK | |
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1]. | |||
T16481 | PF-04995274 | 5-HT Receptor | |
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a... | |||
T15799 | LY2940094 | LY-2940094 | Opioid Receptor |
LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist pot... | |||
T14782 | Brilaroxazine | RP5063 | Dopamine Receptor , 5-HT Receptor |
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... | |||
T7805 | GW791343 dihydrochloride | GW791343 (HCl) | P2X Receptor |
GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator. | |||
T3933 | Jatrorrhizine | Yatrorizine,neprotin | MAO , 5-HT Receptor , Antibacterial , AChE |
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo... | |||
T1279 | Vilazodone | SB659746A,EMD 68843 | 5-HT Receptor , Serotonin Transporter |
Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from... | |||
T1445 | Agomelatine | Thymanax,S-20098,Valdoxan | Melatonin Receptor , 5-HT Receptor |
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. | |||
T4912 | Jatrorrhizine chloride | Yatrorhizine chloride,Neprotine chloride | Others , 5-HT Receptor , OCT , Antibacterial , AChE |
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... | |||
T5135 | Flupentixol dihydrochloride | Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride | Dopamine Receptor |
Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders. | |||
T1471 | Duloxetine hydrochloride | Duloxetine HCl,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl | Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine |
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and i... | |||
T6526 | GW791343 trihydrochloride | GW791343 3HCl | P2X Receptor |
GW791343 trihydrochloride (GW791343 3HCl) is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7. | |||
T1619 | Trazodone hydrochloride | KB-831,Trazodone HCl,AF-1161 | 5-HT Receptor , Adrenergic Receptor , Histamine Receptor |
Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressi... | |||
T0338 | Minaprine | Cantor,Minaprine dihydrochloride,Minaprina,Minaprinum | MAO , Dopamine Receptor , 5-HT Receptor , AChR , AChE , Monoamine Oxidase |
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states. | |||
T27599 | Imiloxan | RS-21361,RS 21361,RS21361 | Adrenergic Receptor |
Imiloxan (RS-21361) is an α2 adrenergic receptor antagonist used in the treatment of major depressive disorder. | |||
T10075 | 2-Methyl-5-HT | 2-Methyl-5-hydroxytryptamine | 5-HT Receptor |
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects. | |||
T68172 | Zalospirone | 5-HT Receptor | |
Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder. | |||
T32737 | Liafensine | BMS820836,BMS 820836,DB104,BMS-820836 | Dopamine Receptor , 5-HT Receptor , Norepinephrine |
Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and centra... |