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Duloxetine hydrochloride

Name: Duloxetine hydrochloride
Brand: TargetMol
SKU: T1471
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1471Cas No. 136434-34-9

Alias LY-248686 hydrochloride, LY-248686 HCl, Duloxetine HCl, (S)-Duloxetine hydrochloride

Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for serotonin and noradrenaline (SNRI). It is an antidepressant agent and anxiolytic, also used for treating pain in patients with diabetes mellitus and fibromyalgia.

Duloxetine hydrochloride

🥰Excellent

Purity: 99.93%

Catalog No. T1471Alias LY-248686 hydrochloride, LY-248686 HCl, Duloxetine HCl, (S)-Duloxetine hydrochlorideCas No. 136434-34-9

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$48	In Stock	In Stock
50 mg	$78	In Stock	In Stock
100 mg	$108	In Stock	In Stock
200 mg	$135	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Color:White

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Bioactivity

Description	Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for serotonin and noradrenaline (SNRI). It is an antidepressant agent and anxiolytic, also used for treating pain in patients with diabetes mellitus and fibromyalgia.
Targets&IC50	SNRI:4.6 nM(Ki)
Synonyms	LY-248686 hydrochloride, LY-248686 HCl, Duloxetine HCl, (S)-Duloxetine hydrochloride

Chemical Properties

Molecular Weight	333.88
Formula	C₁₈H₂₀ClNOS
Cas No.	136434-34-9
Smiles	s1cccc1[C@@H](Oc1cccc2c1cccc2)CCNC.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (748.77 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9951 mL	14.9754 mL	29.9509 mL	149.7544 mL
5 mM	0.5990 mL	2.9951 mL	5.9902 mL	29.9509 mL
10 mM	0.2995 mL	1.4975 mL	2.9951 mL	14.9754 mL
20 mM	0.1498 mL	0.7488 mL	1.4975 mL	7.4877 mL
50 mM	0.0599 mL	0.2995 mL	0.5990 mL	2.9951 mL
100 mM	0.0300 mL	0.1498 mL	0.2995 mL	1.4975 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc