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Duloxetine hydrochloride

🥰Excellent
Catalog No. T1471Cas No. 136434-34-9
Alias LY-248686 hydrochloride, LY-248686 HCl, Duloxetine HCl, (S)-Duloxetine hydrochloride

Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for serotonin and noradrenaline (SNRI). It is an antidepressant agent and anxiolytic, also used for treating pain in patients with diabetes mellitus and fibromyalgia.

Duloxetine hydrochloride
Other Forms of Duloxetine hydrochloride:

Duloxetine hydrochloride

🥰Excellent
Purity: 100%
Catalog No. T1471Alias LY-248686 hydrochloride, LY-248686 HCl, Duloxetine HCl, (S)-Duloxetine hydrochlorideCas No. 136434-34-9
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for serotonin and noradrenaline (SNRI). It is an antidepressant agent and anxiolytic, also used for treating pain in patients with diabetes mellitus and fibromyalgia.
Pack SizePriceAvailabilityQuantity
10 mg$48In Stock
50 mg$78In Stock
100 mg$108In Stock
200 mg$135In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for serotonin and noradrenaline (SNRI). It is an antidepressant agent and anxiolytic, also used for treating pain in patients with diabetes mellitus and fibromyalgia.
Targets&IC50
SNRI:4.6 nM(Ki)
AliasLY-248686 hydrochloride, LY-248686 HCl, Duloxetine HCl, (S)-Duloxetine hydrochloride
Chemical Properties
Molecular Weight333.88
FormulaC18H20ClNOS
Cas No.136434-34-9
Smiless1cccc1[C@@H](Oc1cccc2c1cccc2)CCNC.Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (119.8 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9951 mL14.9754 mL29.9509 mL149.7544 mL
5 mM0.5990 mL2.9951 mL5.9902 mL29.9509 mL
10 mM0.2995 mL1.4975 mL2.9951 mL14.9754 mL
20 mM0.1498 mL0.7488 mL1.4975 mL7.4877 mL
50 mM0.0599 mL0.2995 mL0.5990 mL2.9951 mL
100 mM0.0300 mL0.1498 mL0.2995 mL1.4975 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

SLC6A4Sert (Sodium-dependent)SERTSerotoninTransporterSerotonin TransporterpainosteoarthiritisNoradrenaline transporter (Sodium-dependent)musculoskeletalLY-248686 HydrochlorideLY248686 HydrochlorideLY-248686LY248686LY 248686 HydrochlorideLY 248686InhibitorinhibitgeneralizedDuloxetine hydrochlorideDuloxetine HydrochlorideDuloxetineDopamineReceptorDopamine ReceptordisorderdepressiveDA transporteranxiety5-HTT5HTReceptor5HT Receptor(S)-Duloxetine
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