depressant — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3858	Macranthoidin A		Others
	Macranthoidin A has anti-inflammation activity.		Others
T0692	Allopurinol	Zyloric,Zyloprim,Lopurin	ROS , Xanthine Oxidase
	Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.		ROS , Xanthine Oxidase
T23394	SR 57227A	SR 57227 hydrochloride	5-HT Receptor
	SR 57227A (SR 57227 hydrochloride) is a potent, orally active and selective 5-HT3 receptor agonist. It with ability to cross the blood brain barrier. It has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 rece...		5-HT Receptor
T0318	Azacyclonol	Ataractan,γ-pipradol,MDL 4829,MER 17	5-HT Receptor
	Azacyclonol (MER 17) is a drug used to diminish hallucinations in psychotic individuals.		5-HT Receptor
T6376	Allopurinol Sodium	Allopurinol sodium salt,Sodium allopurinol	ROS
	Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.		ROS
T78556	Antidepressant agent 5		Others
	Antidepressant agent 5 is a 7-substituted tetrahydroisoquinoline derivative with antidepressant activity.Antidepressant agent 5 acts similarly to magnoflorine in the study of depression and can be used for the prevention...		Others
T75003	Antidepressant agent 4
	Antidepressant agent 4, an orally active compound, demonstrates efficacy as an antidepressant with additional anxiolytic, performance-enhancing, and nootropic activities [1].
T75002	Antidepressant agent 3
	Antidepressant agent 3, an orally active compound, showcases multifaceted pharmacological properties including antidepressant, anxiolytic, performance-enhancing, and nootropic activities [1].
T62495	Antidepressant agent 2
	Antidepressant agent 2 showed significant antidepressant effects with a MED value of 0.1 mg/kg.
T10332	Antidepressant agent 1		Others
	Antidepressant agent 1 is a pyrazidole-halogeno-derivative with antidepressant effects. It also can be used to increase body temperature.		Others
T15812	LY2979165	mGlu2 agonist	GluR
	LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.		GluR
T11097	Drobuline hydrochloride		Others
	Drobuline hydrochloride is an anti-arrhythmic agent with cardiac depressant activity.		Others
T2990	Phenibut	Phenybut,Fenigam,Fenibut,PhGABA,Aminophenylbutyric acid,β-Phenyl-γ-aminobutyric acid	GABA Receptor
	Phenibut (Aminophenylbutyric acid) is a central depressant and derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA).		GABA Receptor
T2S2335	Dehydroevodiamine	DHED	Others , NF-κB , COX , PGE Synthase , NO Synthase
	Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood fl...		Others , NF-κB , COX , PGE Synthase , NO Synthase
T0235	Modaline sulfate		MAO , Monoamine Oxidase
	Modaline was a 2-methyl-3-piperidinopyrazine derivative found to inhibit monoamine oxidase (MAO) and showed a curative effect for the anti-depressant. Similar to other MAO inhibitors, it enhanced convulsions induced by t...		MAO , Monoamine Oxidase
T4S1519	Pseudoginsenoside RT5		Others
	1. Pseudoginsenoside RT5 has anti-epilepsy, anti-depressant activity by promoting nerve growth and improve cognitive ability. 2. Pseudoginsenoside RT5 has anti-bacterial, anti-tumor and anti-malaria activities.		Others
T6649	(S)-(+)-Rolipram	(S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram	Apoptosis , PDE
	(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.		Apoptosis , PDE
T1144	Lidocaine hydrochloride	Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin	Apoptosis , ERK , NF-κB , MEK , Sodium Channel
	Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its ...		Apoptosis , ERK , NF-κB , MEK , Sodium Channel
T9846	5-HT3 antagonist 5
	5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound which is a 5-HT 3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT 3 agonist and 2-methyl-5-HT, and exhibits anti-depressant effect in mice [1].
T1320	Disopyramide	Triombrin,Hypaque sodium,amidotrizoate sodium	Potassium Channel , Sodium Channel , AChR
	Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the h...		Potassium Channel , Sodium Channel , AChR