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Search Results for " bone-protective "

7

Compounds

Cat No. Product Name Synonyms Targets
T6374 Alfacalcidol Bondiol,Etalpha,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol Others
Alfacalcidol (Etalpha) (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.
T5751 Tigogenin Others
Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.
T6S2140 β-Anhydroicaritin Anhydroicaritin,Beta-Anhydroicaritin MMP , Others , TNF , Interleukin
1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical ...
TL0008 Gigantol Wnt/beta-catenin , Glucosidase
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...
T6677 Sophocarpine ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
TN4394 Kobophenol A MMP , BCL , p38 MAPK , NF-κB , ROS , DNA/RNA Synthesis , CDK , JNK
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell death. Kobophenol A inhibits AChE activity in a dose-depen...
T68306 INCB16562
INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced p...
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