anxiolytic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23445	Anxiolytic/nonsedative agent-1	TCS 1205	GABA Receptor
	Anxiolytic/nonsedative agent-1 (TCS 1205) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α...		GABA Receptor
T15275	Fenobam		GluR
	Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric mo...		GluR
T5661	Methyl isoeugenol		Others
	methyl isoeugenol (MIE) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food addit...		Others
T3886	Rosavin	Rosavidin	P450
	Rosavin (Rosavidin) has antidepressant and anxiolytic actions, helps balance all the neurotransmitters.		P450
T9626	Cycloleucine		NMDAR
	Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic ef...		NMDAR
T1292	Tiapride hydrochloride		Dopamine Receptor
	Tiapride is a selective blocker of D2/3 dopamine receptors in the brain. It is used in the therapy of various psychiatric and neurological disorders containing dyskinesia, negative symptoms of psychosis, alcohol withdraw...		Dopamine Receptor
T34896	Tofisopam	Emandaxin,Grandaxin	Others
	Tofisopam (Grandaxin) is a 2,3-benzodiazepine compound with anxiolytic activity that can be taken orally.		Others
T2599	Pirenperone		5-HT Receptor
	Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action.		5-HT Receptor
T4508	Glycyl-L-Histidyl-L-Lysine		Others
	Glycyl-L-histidyl-L-lysine is a liver cell growth factor and an asynthetic hepatotrophic agent that stimulates hepatic erythropoietic factor production.		Others
T13318	VU0650786		GluR
	VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents.		GluR
T27475	GSK356278	GSK-356278,GSK 356278	PDE
	GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognitio...		PDE
T19680	Zotepine		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second...
T15286	Flindokalner	BMS-204352	Potassium Channel
	Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p...		Potassium Channel
T6022	LY404039	pomaglumetad	Glucocorticoid Receptor , GluR
	LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).		Glucocorticoid Receptor , GluR
T21995	XAP044		GluR
	XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1].		GluR
T8004	SNAP 94847 hydrochloride		GPR , Melanin-concentrating Hormone Receptor (MCHR)
	SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)		GPR , Melanin-concentrating Hormone Receptor (MCHR)
T4176	Rac-BHFF	(R,S)-BHFF	GABA Receptor
	rac-BHFF ((R,S)-BHFF) is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo an...		GABA Receptor
T8887	2'MeO6MF		GABA Receptor
	2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response...		GABA Receptor
T8357	SB-200646		5-HT Receptor
	SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor		5-HT Receptor
TQ0311	GSK163090		Dopamine Receptor , 5-HT Receptor
	GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).		Dopamine Receptor , 5-HT Receptor