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Zotepine

Catalog No. T19680   CAS 26615-21-4

Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania.

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Zotepine Chemical Structure
Zotepine, CAS 26615-21-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 40.00
2 mg In stock $ 58.00
5 mg In stock $ 95.00
10 mg In stock $ 155.00
25 mg In stock $ 313.00
50 mg In stock $ 538.00
100 mg In stock $ 768.00
1 mL * 10 mM (in DMSO) In stock $ 126.00
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Purity: 99.67%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania.
Targets&IC50 5-HT2C:3.2 nM(Kd), 5-HT2A:2.6 nM(Kd), H1 receptor:3.3 nM(Kd)
Molecular Weight 331.86
Formula C18H18ClNOS
CAS No. 26615-21-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (75.33 mM), sonification is recommended.

TargetMolReferences and Literature

1. Chan HY, Lin AS, Chen KP, Cheng JS, Chen YY, Tsai CJ. An open-label, randomized, controlled trial of zotepine and risperidone for acutely ill, hospitalized, schizophrenic patients with symptoms of agitation. J Clin Psychopharmacol. 2013 Dec;33(6):747-52. doi: 10.1097/JCP.0b013e31829e8168. PubMed PMID: 24100785. 2. Lin CC, Chiu HJ, Chen JY, Liou YJ, Wang YC, Chen TT, Bai YM. Switching from clozapine to zotepine in patients with schizophrenia: a 12-week prospective, randomized, rater blind, and parallel study. J Clin Psychopharmacol. 2013 Apr;33(2):211-4. doi: 10.1097/JCP.0b013e31828700c7. PubMed PMID: 23422395. 3. Khairkar P, Gupta N, Varma SK. Zotepine-induced convulsive seizures in a chronic case of treatment resistant paranoid schizophrenia. Indian J Pharmacol. 2013 Jan-Feb;45(1):95-7. doi: 10.4103/0253-7613.106447. PubMed PMID: 23543675; PubMed Central PMCID: PMC3608308. 4. Chen IM, Hsieh MH, Hwang TJ, Liu CC. Zotepine-related myopathy in a patient with schizophrenia. Eur J Clin Pharmacol. 2013 Mar;69(3):725-6. doi: 10.1007/s00228-012-1346-y. Epub 2012 Jul 14. PubMed PMID: 22797903.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Adrenergic Receptor-Targeted Compound Library Antidepressant Compound Library Human Metabolite Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Inhibitor Library Anti-Hypertension Compound Library

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Keywords

Zotepine 26615-21-4 GPCR/G Protein Immunology/Inflammation Neuroscience Dopamine Receptor 5-HT Receptor Histamine Receptor Adrenergic Receptor antipsychotic antidepressive Serotonin Receptor Inhibitor anxiolytic inhibit 5-hydroxytryptamine Receptor Beta Receptor inhibitor

 

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