Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 40.00 | |
2 mg | In stock | $ 58.00 | |
5 mg | In stock | $ 95.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 538.00 | |
100 mg | In stock | $ 768.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 126.00 |
Description | Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania. |
Targets&IC50 | 5-HT2C:3.2 nM(Kd), 5-HT2A:2.6 nM(Kd), H1 receptor:3.3 nM(Kd) |
Molecular Weight | 331.86 |
Formula | C18H18ClNOS |
CAS No. | 26615-21-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (75.33 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Zotepine 26615-21-4 GPCR/G Protein Immunology/Inflammation Neuroscience Dopamine Receptor 5-HT Receptor Histamine Receptor Adrenergic Receptor antipsychotic antidepressive Serotonin Receptor Inhibitor anxiolytic inhibit 5-hydroxytryptamine Receptor Beta Receptor inhibitor