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Tofisopam

Catalog No. T34896 CAS 22345-47-7

Synonyms: Emandaxin, Grandaxin

Tofisopam (Grandaxin) is a 2,3-benzodiazepine compound with anxiolytic activity that can be taken orally.

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Tofisopam, CAS 22345-47-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 177.00
50 mg	In stock	$ 253.00
100 mg	In stock	$ 372.00
200 mg	In stock	$ 545.00
1 mL * 10 mM (in DMSO)	In stock	$ 85.00

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Purity: 99.59%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Tofisopam (Grandaxin) is a 2,3-benzodiazepine compound with anxiolytic activity that can be taken orally.

In vivo

Tofisopam (30 and 100 mg/kg, po) significantly inhibited the gastric ulceration induced by water-immersion stress in normal rats in a dose-dependent manner. Immobilization-stress loading increased the incidence and average index of gastric ulceration in OB rats, compared with nonstressed rats. Tofisopam (100 mg/kg, po) significantly inhibited the gastric ulceration induced by stress loading in OB rats. Water-immersion stress loading induced a significant increase in intestinal propulsion in rats. This increase was reversed to control levels by tofisopam (100 mg/kg, po). Tofisopam (1.0 mg/kg, iv, or 0.1 mg/kg by intracerebrospinal injection) inhibited the constriction of ear microvessels, the decrease in earlobe temperature, and mydriasis induced by electrical stimulation of the medial hypothalamic area in rabbits[2].

Synonyms	Emandaxin, Grandaxin
Molecular Weight	382.45
Formula	C22H26N2O4
CAS No.	22345-47-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (130.74 mM)

References and Literature

1. Hatayama M, Sumida C, Kurajoh M, Shiraishi J, Okazaki H, Shoji T, Koyama H, Tsutsumi Z, Moriwaki Y, Namba M, Yamamoto T. Acute Effects of Oral Tofisopam on Plasma Concentration and Urinary Excretion of Uric Acid and Oxypurinol. Curr Clin Pharmacol. 2015 Jan 26. [Epub ahead of print] PubMed PMID: 25619490. 2. Ramadan NK, Mohamed AO, Fouad RM, Moustafa AA. Different techniques for the determination of tofisopam. J AOAC Int. 2014 Jan-Feb;97(1):105-13. PubMed PMID: 24672866. 3. Abrushanian ÉB, Popov AV. [Pineal hormone melatonin in low doses potentiates psychotropic and chronotropic activity of tofisopam in rats]. Eksp Klin Farmakol. 2013;76(4):15-7. Russian. PubMed PMID: 23762983. 4. Bihel FJ, Justiniano H, Schmitt M, Hellal M, Ibrahim MA, Lugnier C, Bourguignon JJ. New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6567-72. doi: 10.1016/j.bmcl.2011.08.036. Epub 2011 Aug 12. PubMed PMID: 21920746.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library Human Metabolite Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max Approved Drug Library Orally Active Compound Library

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tofisopam 22345-47-7 Others Emandaxin anxiolytic agent inhibit orally active Inhibitor Grandaxin inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.