Search Result

Search Results for " ap2 "

Targets

AAK1 (AP2 associated kinase 1) AAK1 (AP2 associated kinase 1)

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T12885	SGC-AAK1-1		AAK1 (AP2 associated kinase 1)
	SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe.		AAK1 (AP2 associated kinase 1)
T15781	LP-935509		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
	LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-...		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
T14299	AP20187	B/B Homodimerizer	Others
	AP20187 (B/B Homodimerizer) is a cell-permeable compound employed to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein...		Others
T68455	AP23846	AP-23846	Src
	AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream angiogenic processes in human solid tumor cell lines.		Src
T62861	ERAP2-IN-1
	ERAP2-IN-1 (compound 61) is a non-competitive inhibitor of ERAP2. ERAP2-IN-1 specifically inhibits the hydrolytic activity of ERAP2 peptides, inhibiting Arg-AMC hydrolysis (IC50: 27 μM) and the hydrolytic activity of mod...
T63986	SAP2-IN-1
	SAP2-IN-1 is a secreted aspartate protease 2 (SAP2) inhibitor that exhibits potent SAP2 inhibition (IC50: 0.92 μM). SAP2-IN-1 is also a virulence factor inhibitor and is not active in vitro. SAP2-IN-1 can be used to stud...
T82683	Connexin mimetic peptide 40GAP27
	Connexin mimetic peptide 40GAP27, corresponding to the GAP27 domain of the second extracellular loop of the dominant vascular connexin (Cx40), designated as 40Gap27, is a biologically active peptide utilized to study the...
T82684	Connexin mimetic peptide 40,37GAP26
	Connexin mimetic peptide 40,37GAP26, a biologically active peptide, matches the GAP26 domain of the extracellular loop of major vascular connexins Cx37 and Cx40, referred to as 37,40Gap26 based on Cx homology. It has bee...
T36240	AP219
	AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an ...
T68325	AP24163
	AP24163 is an inhibitor of the gatekeeper mutant of BCR-ABL, thereby suppressing in vitro resistance.
T68607	AP23848
	AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth.
TP2123	ShK-Dap22
	Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4...
T78129	MetAP2-IN-1		Others
	MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].		Others
T68581	AP23464
	AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ab...
T69700	BAP2
	BAP2 is a novel inhibitor of protein disulfide isomerase (PDI).
T7621	6-Thioinosine	6-Mercaptopurine riboside,6TI	Nucleoside Antimetabolite/Analog
	6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.		Nucleoside Antimetabolite/Analog
T15506	HTS01037		Others
	HTS01037 is an inhibitor of fatty acid-binding. HTS01037 is a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki: 0.67 μM).		Others
T77333L	(Iso)-BMT-124110 Formate	(R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）	AAK1 (AP2 associated kinase 1)
	(Iso)-BMT-124110 Formate has an inhibitory effect on the protein serine/threonine kinase AAK, and is used in the treatment of Parkinson's disease, schizophrenia, neuropathic pain, and Alzheimer's disease.		AAK1 (AP2 associated kinase 1)
T34630	SGC-AAK1-1N	SGCAAK11N,SGCAAK1-1N,SGC-AAK11N
	SGC-AAK1-1N is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) with an IC 50 of 1.8 μM [1].
T63355	BMS-309403 sodium
	BMS-309403 sodium is a potent, orally active, selective inhibitor of the adipocyte fatty acid binding protein (FABP4, aP2), demonstrating inhibitory constants (K i ) of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, re...
T14072	A-443654		ERK , VEGFR , GSK-3 , FLT , Casein Kinase , MAPK , Akt , PKA , Chk , CDK , Src , PKC , S6 Kinase
	A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).

Compounds

SGC-AAK1-1

T12885

Synonym:

Target: AAK1 (AP2 associated kinase 1)

LP-935509

T15781

Synonym:

Target: Serine/threonin kinase, AAK1 (AP2 associated kinase 1)

AP20187

T14299

Synonym: B/B Homodimerizer

Connexin mimetic peptide 40GAP27

T82683

Synonym:

Target:

Connexin mimetic peptide 40,37GAP26

Synonym: 6-Mercaptopurine riboside,6TI

Target: Nucleoside Antimetabolite/Analog

(Iso)-BMT-124110 Formate

T77333L

Synonym: (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）

Target: AAK1 (AP2 associated kinase 1)

SGC-AAK1-1N

T34630

Synonym: SGCAAK11N,SGCAAK1-1N,SGC-AAK11N

Target: ERK, VEGFR, GSK-3, FLT, Casein Kinase, MAPK, Akt, PKA, Chk, CDK, Src, PKC, S6 Kinase

Cat No.	Product Name	Synonyms	Targets
TN3882	Dodoviscin A		cAMP , Tyrosinase , transporter
	Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059.Dodoviscin A can promote a...		cAMP , Tyrosinase , transporter

Natural Products

Dodoviscin A

TN3882

Synonym:

Target: cAMP, Tyrosinase, transporter

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02949	AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)	Human	E. coli
	TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of imp...
TMPY-01482	FABP4 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	FABP4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is P04117.
TMPY-02103	FABP4 Protein, Human, Recombinant (29 Ala/Thr, His)	Human	E. coli
	FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16 kDa and the accession number is P15090.
TMPY-00018	METAP2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	METAP2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 54.3 kDa and the accession number is A0A140VJE3.
TMPJ-01356	NECAP2 Protein, Human, Recombinant (His)	Human	E. coli
	NECAP2 belongs to the NECAP family. The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Adaptin ear-binding coat-associated protein 2 can inter...
TMPY-02921	CDK2AP2 Protein, Human, Recombinant (His)	Human	E. coli
	CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including...
TMPH-01250	MAP2K3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that...
TMPY-02727	METAP2 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	METAP2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 54.3 kDa and the accession number is O08663.
TMPH-00943	AP2M1 Protein, Human, Recombinant (His)	Human	E. coli
	AP2M1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-00992	ERAP2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum ...
TMPH-02162	Synaptotagmin-1 Protein, Human, Recombinant (His)	Human	E. coli
	Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. I...