ppi — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T28441	PPI-1019	PPI1019,Apan	Beta Amyloid
	PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).		Beta Amyloid
T10217L	Abarelix	R3827,PPI 149	GNRH Receptor
	Abarelix (PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, which is used for prostate cancer treatment.		GNRH Receptor
T69258	PPI-2458
	PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth ...
T72785	PRMT5:MEP50 PPI
	PRMT5:MEP50 PPI, a pioneering inhibitor of the PRMT5:MEP50 protein-protein interaction (PRMT5:MEP50 PPI), demonstrates anti-tumor and anti-proliferative effects in lung and prostate cancer cells.
T62447	Paltimatrectinib	PBI-200,PPI-5278	Trk receptor , Tyrosine Kinases
	Paltimatrectinib (PBI-200) is a potent tyrosine kinase inhibitor with anticancer activity that inhibits myosin-related kinase A (TrkA).Paltimatrectinib is used in the study of bladder, breast and colorectal cancers.		Trk receptor , Tyrosine Kinases
T7387	Ceftaroline fosamil	TAK-599,PPI0903	Antibacterial , Antibiotic
	Ceftaroline fosamil (TAK-599) is a cephalosporin, with activity against Gram-positive pathogens.		Antibacterial , Antibiotic
T79457	PEX5-PEX14 PPI-IN-1
	PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an inhibitory constant (Ki) of 53 μM. It effectively inhibits the b...
T10217	Abarelix Acetate (183552-38-7 free base)	PPI 149 Acetate,Abarelix Acetate	Others
	Abarelix (PPI 149; R 3827) Acetate is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research.		Others
T81503	PEX5-PEX14 PPI-IN-2
	Compound 12, also known as PEX5-PEX14 PPI-IN-2, is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor with half-maximal effective concentration (EC50) values of 5 µM in T. b. brucei and 17 µM in HepG2 cells. It is ...
T82758	CDK9-Cyclin T1 PPI-IN-1		CDK
	CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apopt...		CDK
T8784	IGS-1.76		Others
	IGS-1.76 exhibits pronounced affinity towards hNCS-1 and effectively modulates the interaction between hNCS-1 and Ric8a. Moreover, IGS-1.76 proficiently inhibits the complex formed by human NCS-1 and Ric8a.		Others
T26859	BMS-8		PD-1/PD-L1
	BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.		PD-1/PD-L1
T4647	M2I-1	M2I 1	Others
	M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 cri...		Others
T6889	MI-136		Apoptosis , Epigenetic Reader Domain , Androgen Receptor
	MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.		Apoptosis , Epigenetic Reader Domain , Androgen Receptor
T9039	HIV-1 Nef-IN-1		HIV Protease
	HIV-1 Nef-IN-1 is an inhibitor of HIV-1 Nef protein. It efficiently competes for Nef-SH3Hck interactions(Kd : 6.7 μM).		HIV Protease
T9044	SORT-PGRN interaction inhibitor 1		Neurotensin Receptor
	SORT-PGRN interaction inhibitor 1 is a potent sortilin-progranulin interaction inhibitor(IC50 of 2 μM).		Neurotensin Receptor
T13018	SU3327	halicin	JNK
	SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).		JNK
T8421	TED-347		YAP
	TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.		YAP
T8216	T-1101 tosylate	TAI-95 tosylate	Apoptosis , Microtubule Associated
	T-1101 tosylate (TAI-95 tosylate) is an inhibitor of Hec1/Nek2, with antitumor activity.		Apoptosis , Microtubule Associated
T6928	Pantoprazole	SKF96022,BY1023	Apoptosis , Proton pump , Autophagy
	Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.		Apoptosis , Proton pump , Autophagy