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IGS-1.76

Catalog No. T8784 CAS 313480-47-6

IGS-1.76 exhibits pronounced affinity towards hNCS-1 and effectively modulates the interaction between hNCS-1 and Ric8a. Moreover, IGS-1.76 proficiently inhibits the complex formed by human NCS-1 and Ric8a.

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IGS-1.76, CAS 313480-47-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 249.00
10 mg	In stock	$ 416.00
25 mg	In stock	$ 692.00
50 mg	In stock	$ 985.00
100 mg	In stock	$ 1,330.00
500 mg	In stock	$ 2,660.00
1 mL * 10 mM (in DMSO)	In stock	$ 273.00

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Purity: 98.76%

Purity: 98.56%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	IGS-1.76 exhibits pronounced affinity towards hNCS-1 and effectively modulates the interaction between hNCS-1 and Ric8a. Moreover, IGS-1.76 proficiently inhibits the complex formed by human NCS-1 and Ric8a.
Targets&IC50	TRPC3:0.49 uM
In vitro	IGS-1.76, which efficiently inhibits the human NCS-1/Ric8a complex with improved binding potency.

Molecular Weight	358.46
Formula	C22H18N2OS
CAS No.	313480-47-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (62.77 mM)

References and Literature

1. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14):5910-5921.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max PPI Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IGS-1.76 313480-47-6 Others NCS-1 Ric8a IGS 1.76 PPI inhibit IGS1.76 Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.