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Abarelix
🥰Excellent
Catalog No. T10217LCas No. 183552-38-7
Alias R3827, PPI 149
Abarelix (PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, which is used for prostate cancer treatment.
Abarelix
🥰Excellent
Purity: 100%
Catalog No. T10217LAlias R3827, PPI 149Cas No. 183552-38-7
Abarelix (PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, which is used for prostate cancer treatment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $56 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $189 | In Stock | |
| 50 mg | $297 | In Stock | |
| 100 mg | $455 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $92 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Abarelix (PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, which is used for prostate cancer treatment. |
| In vitro | Abarelix, at concentrations of 30 and 300 µg/mL, significantly increases histamine release[1]. It rapidly and considerably lowers follicle-stimulating hormone levels below those achieved by LHRH agonists. As the inaugural GnRH antagonist developed, Abarelix achieves fast and sustained testosterone reductions to castrate levels without requiring concurrent antiandrogen therapy, exhibiting a remarkably low short-term complication rate[2]. Unlike other treatments, it avoids the testosterone surge that can exacerbate symptoms or disease progression, particularly in patients with metastatic, symptomatic conditions, facilitating quicker medical castration[3]. |
| Alias | R3827, PPI 149 |
| Molecular Weight | 1416.06 |
| Formula | C72H95ClN14O14 |
| Cas No. | 183552-38-7 |
| Smiles | CC(C)C[C@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O |
| Relative Density. | 1.286g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 14.2 mg/mL (10.03 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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