pam — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37075	CB2R PAM	Ec2la	Cannabinoid Receptor
	CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors, but has no effect in the abs...		Cannabinoid Receptor
T37428	TRPC6-PAM-C20	TRPC6-PAM-C20,3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one	TRP/TRPV Channel
	TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced p...		TRP/TRPV Channel
T1111	Pralidoxime Chloride	2-PAM chloride,2-Pyridinealdoxime methochloride,2-PAM (chloride)	AChE
	Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates o...		AChE
T33872	Pam 1392	AI3 52841,AI352841,AI3-52841
	Pam 1392 is a chemotherapeutic agent.
T22404	Pralidoxime Iodide	2-PAM	Others
	Pralidoxime Iodide, also named 2-PAM, is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.		Others
TP2399	Palmitoyl tetrapeptide	Pam-ser-ser-asn-ala
	Palmitoyl tetrapeptide is an analog of the N-terminal part of lipoprotein from the outer membrane of E. coli.
T9177	BPAM344		iGluR
	BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.		iGluR
T23514	VU-1545	VU 1545	GluR
	VU-1545 is mGlu5 positive allosteric modulator.		GluR
T29123	VU0152099	VU 0152099,VU-0152099	AChR
	VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).		AChR
T8991	BMS986187		Opioid Receptor
	BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.		Opioid Receptor
T9021	Ro0711401	Ro-0711401,Ro 0711401	GluR
	Ro0711401 is an agonist of mGlu1 receptor.		GluR
T28069	ML380	ML 380,ML-380	AChR
	ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).		AChR
T29137	VU0453595	VU 0453595,VU-0453595	AChR
	VU0453595 is a M1 positive allosteric modulator (PAM).		AChR
TP1962	Pam2CSK4
	Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.
T7699	AZD7325	AZD-7325	P450 , GABA Receptor
	AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.		P450 , GABA Receptor
TP2282	Pam2CSK4 Biotin		Others
	biotinylated Pam2CSK4, a toll-like receptor 2/6 agonist		Others
T70460	HM5023507
	HM5023507, an orally active dual inhibitor of δγ isoforms in immune signaling. HM5023507 inhibited PI3Kδ and PI3Kγ isoforms with greater than 100-fold selectivity against PI3Kα and PI3Kβ in recombinant enzymatic assays a...
TP1067	Pam3CSK4 TFA (112208-00-1 free base)	Pam3CSK4 TFA,Pam3Cys-Ser-(Lys)4 TFA	TLR
	Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).		TLR
TP1068	Pam3CSK4	Pam3Cys-Ser-(Lys)4
	Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.
T60047	V-0219		Glucagon Receptor
	V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes.		Glucagon Receptor