Powder: -20°C for 3 years | In solvent: -80°C for 2 years
AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 175.00 | |
50 mg | In stock | $ 297.00 | |
100 mg | In stock | $ 447.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | AZD-7325 is a GABA-Aα2,3 -selective receptor modulator. |
In vivo | AZD7325 on synaptic responses was more prominent in mice on the 129S6/SvEvTac background strain that has been demonstrated to be seizure resistant in the model of Dravet syndrome (Scn1a+/?) and in which the α2 GABAA receptor subunits are higher relative to in the C57BL/6J strain.?Consistent with this, treatment of mice with AZD7325 is associated with a higher temperature threshold for hyperthermia-induced seizures in Scn1a+/? mice without apparent sedative effects.?Our results in a model system indicate that selective targeting α2 is a potential therapeutic option for Dravet syndrome[1]. |
Animal Research | Animal Model:Male and female P18 - P20 F1.Scn1a+/- mice. Dosage:10, 17.8 or 31.6 mg/kg. Administration:Oral administration[1] |
Synonyms | AZD-7325 |
Molecular Weight | 354.4 |
Formula | C19H19FN4O2 |
CAS No. | 942437-37-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 9 mg/mL (25.4 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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AZD7325 942437-37-8 Membrane transporter/Ion channel Metabolism Neuroscience GABA Receptor P450 modulator effect inhibit Cytochrome P450 Dravet syndrome Inhibitor γ-Aminobutyric acid Receptor CYPs sedative PAM CYP1A2 Gamma-aminobutyric acid Receptor anxiety AZD 7325 AZD-7325 inhibitor