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AZD7325
🥰Excellent
Catalog No. T7699Cas No. 942437-37-8
Alias AZD-7325
AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.
AZD7325
🥰Excellent
Purity: 99.83%
Catalog No. T7699Alias AZD-7325Cas No. 942437-37-8
AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $64 | In Stock | |
| 10 mg | $97 | In Stock | |
| 25 mg | $175 | In Stock | |
| 50 mg | $297 | In Stock | |
| 100 mg | $447 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $70 | In Stock |
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CitedSelect Batch
Purity:99.83%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator. |
| In vivo | AZD7325 on synaptic responses was more prominent in mice on the 129S6/SvEvTac background strain that has been demonstrated to be seizure resistant in the model of Dravet syndrome (Scn1a+/?) and in which the α2 GABAA receptor subunits are higher relative to in the C57BL/6J strain.?Consistent with this, treatment of mice with AZD7325 is associated with a higher temperature threshold for hyperthermia-induced seizures in Scn1a+/? mice without apparent sedative effects.?Our results in a model system indicate that selective targeting α2 is a potential therapeutic option for Dravet syndrome[1]. |
| Animal Research | Animal Model:Male and female P18 - P20 F1.Scn1a+/- mice. Dosage:10, 17.8 or 31.6 mg/kg. Administration:Oral administration[1] |
| Alias | AZD-7325 |
| Molecular Weight | 354.38 |
| Formula | C19H19FN4O2 |
| Cas No. | 942437-37-8 |
| Smiles | CCCNC(=O)c1nnc2c(cccc2c1N)-c1c(F)cccc1OC |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (25.4 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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