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AZD7325

Catalog No. T7699 CAS 942437-37-8

Synonyms: AZD-7325

AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AZD7325, CAS 942437-37-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 175.00
50 mg	In stock	$ 297.00
100 mg	In stock	$ 447.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 99.88%

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Description	AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.
In vivo	AZD7325 on synaptic responses was more prominent in mice on the 129S6/SvEvTac background strain that has been demonstrated to be seizure resistant in the model of Dravet syndrome (Scn1a+/?) and in which the α2 GABAA receptor subunits are higher relative to in the C57BL/6J strain.?Consistent with this, treatment of mice with AZD7325 is associated with a higher temperature threshold for hyperthermia-induced seizures in Scn1a+/? mice without apparent sedative effects.?Our results in a model system indicate that selective targeting α2 is a potential therapeutic option for Dravet syndrome[1].
Animal Research	Animal Model:Male and female P18 - P20 F1.Scn1a+/- mice. Dosage:10, 17.8 or 31.6 mg/kg. Administration:Oral administration[1]

Synonyms	AZD-7325
Molecular Weight	354.4
Formula	C19H19FN4O2
CAS No.	942437-37-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 9 mg/mL (25.4 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. ProfileToshihiro Nomura, et al. Potentiating α2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet Syndrome 2. Chen X, et al. The central nervous system effects of the partial GABA-Aα2,3 -selective receptor modulator AZD7325 in comparison with lorazepam in healthy males.Br J Clin Pharmacol. 2014 Dec;78(6):1298-314.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max Orally Active Compound Library Drug Repurposing Compound Library Immunology/Inflammation Compound Library Neurotransmitter Receptor Compound Library Bioactive Compound Library Neuronal Signaling Compound Library Pediatric Drug Library Anti-Cancer Compound Library

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Keywords

AZD7325 942437-37-8 Membrane transporter/Ion channel Metabolism Neuroscience GABA Receptor P450 modulator effect inhibit Cytochrome P450 Dravet syndrome Inhibitor γ-Aminobutyric acid Receptor CYPs sedative PAM CYP1A2 Gamma-aminobutyric acid Receptor anxiety AZD 7325 AZD-7325 inhibitor

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