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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T22889 | KF38789 | KF 38789 | Others |
KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein. | |||
T16676 | PSI-697 | P-Selectin Inhibitor | Others |
PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM). | |||
T78288 | Inclacumab | Anti-Human selectin P Recombinant Antibody | |
Inclacumab, a humanized monoclonal IgG4 antibody (Anti-Human Selectin P Recombinant Antibody), specifically binds to P-selectin with a dissociation constant (Kd) of 9.9 nM. It effectively prevents the interaction between... | |||
T1893 | Parmodulin 2 | ML 161 | Protease-activated Receptor |
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thromb... | |||
T77399 | Crizanlizumab | ADAKVEO,SEG-101 | Others |
Crizanlizumab (Adakveo) is a humanized monoclonal antibody against P-selectin for the prevention of pain crises in sickle cell disease. | |||
T14574 | Bimosiamose | TBC-1269 | Integrin |
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively. | |||
T14573 | Bimosiamose disodium | TBC-1269Z | Integrin |
Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, res... | |||
T24144 | HMCEF | ||
HMCEF is a P-selectin inhibitor that acts by intercalating into calf thymus DNA, cutting off DNA pBR22. It also inhibits the proliferation of cancer cells. | |||
T39121 | Odatroltide | DHDMIQK(KAP),Odatroltide | |
Odatroltide is a nanoscale P-selectin inhibitor that serves as a nano-delivery system for 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to specifically target the thrombus. | |||
T71472 | LN6023 | ||
LN6023 is a ACKR3/CXCR7 Superagonist for Platelet Degranulation Modulation. LN6023 effectively reduced P-selectin expression by up to 97%, suggesting to be a potential candidate for the treatment of platelet-mediated thr... | |||
T25911 | Oxycinchophen | Magnophenyl,Sintofene,Reumartril,Chinoxone | |
Oxycinchophen is a quinoline-like organic, anti-rheumatic compound. It has been used to study P- selectin antagonistic activity, DHOD inhibitory activity, and the effects of anti-inflammatory drugs on vascular smooth mus... | |||
T35884 | Sialyl-Lewis X | ||
Sialyl-Lewis X (sLeX), a sialylated fucosylated tetrasaccharide and endogenous antigen, serves as a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. It interacts with ELAM-1 and CD62, consequently inhibiti... | |||
T60303 | Collagen-IN-1 | ||
Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Coll... | |||
T36221 | 2-chloro Palmitic Acid | ||
2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic aci... | |||
T35494 | (±)11(12)-EET | ||
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms C... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3S0645 | N-trans-Feruloyltyramine | Feruloyltyramine,N-Feruloyltyramine,Moupinamide | Others , COX |
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s... | |||
T4S0498 | Glaucocalyxin A | Wangzaozin B,Leukamenin F | Apoptosis , Akt , Caspase , PI3K |
1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02709 | P-Selectin Protein, Human, Recombinant (His) | Human | HEK293 Cells |
P-Selectin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.4 kDa and the accession number is AAN06828.1. | |||
TMPY-04101 | P-Selectin Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
P-Selectin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.4 kDa and the accession number is Q3MID1. | |||
TMPY-04708 | P-Selectin Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells |
P-Selectin Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 106.8 kDa and the accession number is XP_001094728.1. | |||
TMPY-00244 | P-Selectin Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
P-Selectin Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 98.7 kDa and the accession number is Q3MID1. | |||
TMPY-02643 | P-Selectin Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
P-Selectin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107 kDa and the accession number is AAN06828.1. | |||
TMPY-03531 | PSGL-1/CD162 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
PSGL-1/CD162 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.5 kDa and the accession number is Q14242-1. | |||
TMPY-05013 | PSGL-1/CD162 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
PSGL-1/CD162 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 55.4 kDa and the accession number is AAC50061.1. | |||
TMPY-03702 | P-Selectin Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
P-Selectin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.9 kDa and the accession number is Q01102. | |||
TMPY-03415 | P-Selectin Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
P-Selectin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 99.6 kDa and the accession number is Q01102. | |||
TMPK-00830 | P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells |
Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. A SLe(x)-type proteoglycan, which through high a... | |||
TMPJ-00382 | P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated | Mouse | HEK293 Cells |
P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothel... | |||
TMPJ-00257 | PSGL-1/CD162 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa ... | |||
TMPY-00906 | PSGL-1/CD162 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
PSGL-1/CD162 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 57.1 kDa and the accession number is AAC50061.1. | |||
TMPY-03354 | PSGL-1/CD162 Protein, Mouse, Recombinant | Mouse | HEK293 Cells |
PSGL-1/CD162 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 31.2 kDa and the accession number is Q62170. | |||
TMPY-02353 | PSGL-1/CD162 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
PSGL-1/CD162 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is Q62170. | |||
TMPK-00565 | PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 als... | |||
TMPK-01033 | PSGL-1/CD162 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 als... | |||
TMPJ-00612 | PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc) | Mouse | HEK293 Cells |
P-selectin glycoprotein ligand 1 is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. As such, it plays a critical role in the tethering of these cells to activat... |