Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 347.00 | |
25 mg | 6-8 weeks | $ 1,820.00 | |
50 mg | 6-8 weeks | $ 2,380.00 | |
100 mg | 6-8 weeks | $ 3,100.00 | |
1 mL * 10 mM (in DMSO) | 6-8 weeks | $ 278.00 |
Description | PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM). |
Targets&IC50 | P-selectin:125 μM |
In vitro | PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1. In vitro, as a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM [1]. |
In vivo | PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and reduces inflammation in a baboon model of venous thrombosis. PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis. PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to the vehicle, without prolonging bleeding time in a rat venous thrombosis model. PSI-697 (0-50 mg/kg; p.o.) obviously decreases the number of rolling leukocytes by 39% versus vehicle control[1][2]. |
Synonyms | P-Selectin Inhibitor |
Molecular Weight | 367.83 |
Formula | C21H18ClNO3 |
CAS No. | 851546-61-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.8 mg/mL (124.51 mM)
You can also refer to dose conversion for different animals. More
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PSI-697 851546-61-7 Others PSI 697 P-Selectin Inhibitor PSI697 inhibitor inhibit