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Parmodulin 2

Catalog No. T1893 CAS 423735-93-7

Synonyms: ML 161

Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thrombin-induced platelet activation.

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Parmodulin 2, CAS 423735-93-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 38.00
5 mg	In stock	$ 61.00
10 mg	In stock	$ 85.00
25 mg	In stock	$ 158.00
50 mg	In stock	$ 271.00
100 mg	In stock	$ 490.00
1 mL * 10 mM (in DMSO)	In stock	$ 59.00

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Purity: 99.95%

Purity: 96.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thrombin-induced platelet activation.
Targets&IC50	PAR1:0.26 μM
In vivo	Through P-selectin expression assays, ML-161 has been found to inhibit thrombin-induced platelet activation in a dose-dependent manner. ML-161 selectively inhibits platelet aggregation induced by SFLLRN and thrombin through PAR1 (proteinase-activated receptor 1), without affecting platelet aggregation triggered by AYPGKF, thromboxane, or ADP (adenosine diphosphate).

Synonyms	ML 161
Molecular Weight	361.23
Formula	C17H17BrN2O2
CAS No.	423735-93-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 36.1 mg/mL (100 mM)

Ethanol: 36.1 mg/mL (100 mM)

References and Literature

1. Dockendorff C, et al. ACS Med Chem Lett, 2012, 3(3), 232-237. 2. Bing Z, Wu M, Hu Z, et al. A novel oncotherapy strategy, direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer[J]. Authorea Preprints. 2020 3. Zhao B, Wu M, Hu Z, et al. A novel oncotherapy strategy, direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non‐small cell lung cancer[J]. British Journal of Pharmacology. 2021

Citations

1. Bing Z, Wu M, Hu Z, et al. A novel oncotherapy strategy, direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer. British Journal of Pharmacology. 2020

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library GPCR Compound Library Anti-Obesity Compound Library Bioactive Compound Library Target-Focused Phenotypic Screening Library Bioactive Compounds Library Max NO PAINS Compound Library

Related Products

Related compounds with same targets

Protease-Activated Receptor-1, PAR-1 Agonist acetate PAR-4 Agonist Peptide, amide acetate TRAP-6 amide acetate Protease-Activated Receptor-4 AC-264613 tcY-NH2 TFA(327177-34-4 free base) Vorapaxar sulfate I-191

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Parmodulin 2 423735-93-7 GPCR/G Protein Protease-activated Receptor aggregation receptor SFLLRN-induced PAR1 Protease Activated Receptor (PAR) Thrombin receptors inhibit platelet ML-161 ML 161 protease-activated P-selectin Parmodulin-2 thrombus Parmodulin2 formation Inhibitor ML161 inhibitor

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