Home Tools
Log in
Cart

Bimosiamose

Catalog No. T14574   CAS 187269-40-5
Synonyms: TBC-1269

Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Bimosiamose Chemical Structure
Bimosiamose, CAS 187269-40-5
Pack Size Availability Price/USD Quantity
50 mg Inquiry Inquiry
100 mg Inquiry Inquiry
Bulk Inquiry
Get quote
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
Targets&IC50 L-selectin:86 μM, P-selectin:20 μM, E-selectin:88 μM
In vitro Bimosiamose (TBC-1269) inhibits cell recruitment. And it does not possess any cytotoxic effect on neutrophils. Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment.
In vivo Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1]. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion. It also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion.
Synonyms TBC-1269
Molecular Weight 862.91
Formula C46H54O16
CAS No. 187269-40-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

0.1 M NaOH: 25 mg/mL (28.97 mM), ultrasonic and adjust pH to 10 with NaOH

DMSO: 125 mg/mL (144.86 mM), sonification is recommended.

TargetMolReferences and Literature

1. Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72.

Related Products

Related compounds with same targets
Natalizumab Firategrast 3-Hydroxyxanthone Cyclo(Ala-Arg-Gly-Asp-Mamb) α7β1 integrin modulator-1 Carvedilol phosphate hemihydrate Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base) Vedolizumab

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bimosiamose 187269-40-5 Cytoskeletal Signaling Integrin TBC1269 TBC 1269 TBC-1269 inhibitor inhibit

 

TargetMol