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Bimosiamose

Name: Bimosiamose
Brand: TargetMol
SKU: T14574
Rating: 4.5 (1 reviews)

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Catalog No. T14574Cas No. 187269-40-5

Alias TBC-1269

Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.

Bimosiamose

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Catalog No. T14574Alias TBC-1269Cas No. 187269-40-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$83	35 days	35 days
5 mg	Inquiry	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
Targets&IC50	P-selectin:20 μM, Eselectin:88 μM, L-selectin:86 μM
In vitro	Bimosiamose (TBC-1269) effectively inhibits neutrophil recruitment to inflammation sites by obstructing the initial rolling phase of recruitment, without exhibiting cytotoxic effects on neutrophils.
In vivo	Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment significantly increases survival, ameliorates neutrophil migration by 81%, and improves histologic damage scores[1]. The best overall survival rate of 70% is observed when administered 15 minutes before reperfusion, with a marked decrease in liver enzyme levels at 6 hours after reperfusion.
Synonyms	TBC-1269

Chemical Properties

Molecular Weight	862.91
Formula	C₄₆H₅₄O₁₆
Cas No.	187269-40-5
Smiles	OC[C@H]1O[C@H](Oc2ccc(CCCCCCc3ccc(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)c(c3)-c3cccc(CC(O)=O)c3)cc2-c2cccc(CC(O)=O)c2)[C@@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.417 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.1 M NaOH: 25 mg/mL (28.97 mM), when pH is adjusted to 10 with NaOH. Sonication is recommended.

DMSO: 125 mg/mL (144.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (3.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

0.1 M NaOH/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1589 mL	5.7943 mL	11.5887 mL	57.9435 mL
5 mM	0.2318 mL	1.1589 mL	2.3177 mL	11.5887 mL
10 mM	0.1159 mL	0.5794 mL	1.1589 mL	5.7943 mL
20 mM	0.0579 mL	0.2897 mL	0.5794 mL	2.8972 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0232 mL	0.1159 mL	0.2318 mL	1.1589 mL
100 mM	0.0116 mL	0.0579 mL	0.1159 mL	0.5794 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc