Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
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Description | Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively. |
Targets&IC50 | L-selectin:86 μM, P-selectin:20 μM, E-selectin:88 μM |
In vitro | Bimosiamose (TBC-1269) inhibits cell recruitment. And it does not possess any cytotoxic effect on neutrophils. Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. |
In vivo | Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1]. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion. It also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. |
Synonyms | TBC-1269 |
Molecular Weight | 862.91 |
Formula | C46H54O16 |
CAS No. | 187269-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
0.1 M NaOH: 25 mg/mL (28.97 mM), ultrasonic and adjust pH to 10 with NaOH
DMSO: 125 mg/mL (144.86 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Bimosiamose 187269-40-5 Cytoskeletal Signaling Integrin TBC1269 TBC 1269 TBC-1269 inhibitor inhibit