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Search Results for " p-selectin "

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Targets

Others

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T22889	KF38789	KF 38789	Others
	KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein.		Others
T16676	PSI-697	P-Selectin Inhibitor	Others
	PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM).		Others
T78288	Inclacumab	Anti-Human selectin P Recombinant Antibody
	Inclacumab, a humanized monoclonal IgG4 antibody (Anti-Human Selectin P Recombinant Antibody), specifically binds to P-selectin with a dissociation constant (Kd) of 9.9 nM. It effectively prevents the interaction between...
T1893	Parmodulin 2	ML 161	Protease-activated Receptor
	Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thromb...		Protease-activated Receptor
T77399	Crizanlizumab	ADAKVEO,SEG-101	Others
	Crizanlizumab (Adakveo) is a humanized monoclonal antibody against P-selectin for the prevention of pain crises in sickle cell disease.		Others
T14574	Bimosiamose	TBC-1269	Integrin
	Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.		Integrin
T14573	Bimosiamose disodium	TBC-1269Z	Integrin
	Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, res...		Integrin
T24144	HMCEF
	HMCEF is a P-selectin inhibitor that acts by intercalating into calf thymus DNA, cutting off DNA pBR22. It also inhibits the proliferation of cancer cells.
T39121	Odatroltide	DHDMIQK(KAP),Odatroltide
	Odatroltide is a nanoscale P-selectin inhibitor that serves as a nano-delivery system for 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to specifically target the thrombus.
T71472	LN6023
	LN6023 is a ACKR3/CXCR7 Superagonist for Platelet Degranulation Modulation. LN6023 effectively reduced P-selectin expression by up to 97%, suggesting to be a potential candidate for the treatment of platelet-mediated thr...
T25911	Oxycinchophen	Magnophenyl,Sintofene,Reumartril,Chinoxone
	Oxycinchophen is a quinoline-like organic, anti-rheumatic compound. It has been used to study P- selectin antagonistic activity, DHOD inhibitory activity, and the effects of anti-inflammatory drugs on vascular smooth mus...
T35884	Sialyl-Lewis X
	Sialyl-Lewis X (sLeX), a sialylated fucosylated tetrasaccharide and endogenous antigen, serves as a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. It interacts with ELAM-1 and CD62, consequently inhibiti...
T60303	Collagen-IN-1
	Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Coll...
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic aci...
T35494	(±)11(12)-EET
	(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms C...

Compounds

Synonym: P-Selectin Inhibitor

Target: Others

Inclacumab

T78288

Synonym: Anti-Human selectin P Recombinant Antibody

Target: Protease-activated Receptor

Crizanlizumab

T77399

Synonym: ADAKVEO,SEG-101

Synonym: DHDMIQK(KAP),Odatroltide

Synonym: Magnophenyl,Sintofene,Reumartril,Chinoxone

2-chloro Palmitic Acid

Cat No.	Product Name	Synonyms	Targets
T3S0645	N-trans-Feruloyltyramine	Feruloyltyramine,N-Feruloyltyramine,Moupinamide	Others , COX
	1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s...		Others , COX
T4S0498	Glaucocalyxin A	Wangzaozin B,Leukamenin F	Apoptosis , Akt , Caspase , PI3K
	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi...		Apoptosis , Akt , Caspase , PI3K

Natural Products

N-trans-Feruloyltyramine

T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide

Target: Others, COX

Glaucocalyxin A

T4S0498

Synonym: Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02709	P-Selectin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	P-Selectin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.4 kDa and the accession number is AAN06828.1.
TMPY-04101	P-Selectin Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	P-Selectin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.4 kDa and the accession number is Q3MID1.
TMPY-04708	P-Selectin Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293 Cells
	P-Selectin Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 106.8 kDa and the accession number is XP_001094728.1.
TMPY-00244	P-Selectin Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	P-Selectin Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 98.7 kDa and the accession number is Q3MID1.
TMPY-02643	P-Selectin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	P-Selectin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107 kDa and the accession number is AAN06828.1.
TMPY-05013	PSGL-1/CD162 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	PSGL-1/CD162 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 55.4 kDa and the accession number is AAC50061.1.
TMPY-03531	PSGL-1/CD162 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PSGL-1/CD162 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.5 kDa and the accession number is Q14242-1.
TMPY-03702	P-Selectin Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	P-Selectin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.9 kDa and the accession number is Q01102.
TMPY-03415	P-Selectin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	P-Selectin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 99.6 kDa and the accession number is Q01102.
TMPK-00830	P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. A SLe(x)-type proteoglycan, which through high a...
TMPJ-00382	P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated	Mouse	HEK293 Cells
	P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothel...
TMPJ-00257	PSGL-1/CD162 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa ...
TMPY-00906	PSGL-1/CD162 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	PSGL-1/CD162 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 57.1 kDa and the accession number is AAC50061.1.
TMPY-03354	PSGL-1/CD162 Protein, Mouse, Recombinant	Mouse	HEK293 Cells
	PSGL-1/CD162 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 31.2 kDa and the accession number is Q62170.
TMPY-02353	PSGL-1/CD162 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	PSGL-1/CD162 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is Q62170.
TMPK-00565	PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 als...
TMPK-01033	PSGL-1/CD162 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 als...
TMPJ-00612	PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc)	Mouse	HEK293 Cells
	P-selectin glycoprotein ligand 1 is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. As such, it plays a critical role in the tethering of these cells to activat...