janus — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T32264	Janus green	C.I. 11045,EINECS 225-029-8,Janus Green G
	Janus green is a basic dye.
T32265	Janus red	NSC-9609,NSC9609,Janus Red B,NSC 9609,C.I. 26115
	Janus red is a basic dye.
T20027	Janus green B	NSC13986,NSC 13986,Janus Green V,NSC-13986
	Janus green B is an agent of basic dye.
T32263	Janus blue	C.I. 12210,Indoine Blue R,EINECS 224-951-8,C.I. Basic Blue 16,Indazol Blue R
	Janus blue is a basic dye.
T3080	Pyridone 6	Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I	Tyrosine Kinases , JAK
	Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM...		Tyrosine Kinases , JAK
T38624	Fosifidancitinib		JAK
	Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.		JAK
T11710	JAK-IN-5		JAK
	JAK-IN-5 is a JAK inhibitor.		JAK
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
T3069	AZD-1480		JAK
	AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies...		JAK
T4210	SAR-20347	SAR20347	Tyrosine Kinases , JAK
	SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).		Tyrosine Kinases , JAK
T5091	FM-381	FM381	JAK
	FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.		JAK
T6790	BMS-911543	BMS911543	Tyrosine Kinases , Histone Methyltransferase , JAK
	BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.		Tyrosine Kinases , Histone Methyltransferase , JAK
T5492	JAK3-IN-6		JAK
	JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM		JAK
T2156	WP1066		Apoptosis , JAK , STAT
	WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Bra...		Apoptosis , JAK , STAT
T6122	CEP-33779	CEP33779	JAK
	CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.		JAK
T8546	BD750		JAK , STAT
	BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in mouse and human T cells, respectively)		JAK , STAT
T39113L	Povorcitinib phosphate		JAK
	Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.		JAK
TJS1779	Protosappanin A	PTA	NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT
	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory ...
T6838	FLLL32		Apoptosis , JAK , STAT
	FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).		Apoptosis , JAK , STAT
TQ0010	Brepocitinib	PF-06700841	Tyrosine Kinases , JAK
	Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).		Tyrosine Kinases , JAK