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FLLL32

Catalog No. T6838 CAS 1226895-15-3

FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).

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FLLL32, CAS 1226895-15-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 38.00
5 mg	In stock	$ 61.00
10 mg	In stock	$ 85.00
25 mg	In stock	$ 126.00
50 mg	In stock	$ 207.00
100 mg	In stock	$ 369.00
500 mg	In stock	$ 885.00
1 mL * 10 mM (in DMSO)	In stock	$ 66.00

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Purity: 99.8%

Purity: 96.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
Targets&IC50	JAK2:<5 μM
In vitro	In MDA-MB-231 breast and PANC-1 pancreatic cancer cells, FLLL32 downregulates STAT3 phosphorylation and DNA-binding activity. In MDA-MB-231 cells, FLLL32 inhibit the formation of colonies and cell invasion. [1] In human multiple myeloma, glioblastoma, liver cancer, and colorectal cancer cell lines, FLLL32 also leads to the inhibition of cell proliferation and the induction of caspase-3 and PARP cleavages. [2]
In vivo	In MDA-MB-231 xenografted mice, FLLL32 (50 mg/kg, i.p.) significantly reduces tumor burdens. [1] In mouse xenografts with OS-33 osteosarcoma cells, FLLL32 (50 mg/kg, i.p.) also inhibits tumor growth by targeting STAT3. [3]
Kinase Assay	JAK2 and other human kinase activity assays: JAK2 kinase activity was assessed with the HTScan JAK2 Kinase Assay Kit per manufacturer's protocol. The possible effects of FLLL32 on the other 10 purified human protein kinases were determined by using a Kinase Profiler Assay.
Cell Research	Cells are seeded in 96-well plates (3,000 per well) in triplicate and then treated with 0.5 to 5 μM of FLLL31 or FLLL32 or with 0.5 to 30 μM of curcumin for 72 h. MTT (25 μL) is added to each sample and incubated for 3.5 h. Then, 100 μL of N,N-dimethylformamide solubilization solution are added to each well. The absorbance at 450 nm is read the following day. IC50 are determined using Sigma Plot 9.0 software.(Only for Reference)

Molecular Weight	464.55
Formula	C28H32O6
CAS No.	1226895-15-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 85 mg/mL (183 mM)

Ethanol: 24 mg/mL (51.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Lin L, et al. Cancer Res. 2010, 70(6), 2445-2454. 2. Lin L, et al. Mol Cancer. 2010, 9, 217. 3. Wattenberg LW, et al. Invest New Drugs. 2012, 30(3, 916-926.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library Anti-Cancer Active Compound Library Anti-Liver Cancer Compound Library Reprogramming Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Anti-Cancer Metabolism Compound Library Epigenetics Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FLLL32 1226895-15-3 Angiogenesis Apoptosis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK STAT FLLL 32 inhibit FLLL-32 Inhibitor Janus kinase inhibitor

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