hiv-in-5 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64048	HIV-IN-5
	HIV-IN-5 (compound 5r) is a potent inhibitor of HIV-1 (IC50: 0.16 μM). HIV-IN-5 binds to NNIBP (NNRTIs (non-nucleoside reverse transcriptase inhibitors) binding sites). ).
T64112	HIV-1 protease-IN-5
	HIV-1 protease-IN-5 is an HIV-1 protease inhibitor (IC50: 1.64 nM). HIV-1 protease-IN-5 exhibits significant effects on wild-type and DRV-resistant HIV-1.
T63143	DENV-IN-5		Virus Protease , HIV Protease
	Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.		Virus Protease , HIV Protease
T25913L	P-113 acetate		HIV Protease , Antibacterial , Antibiotic
	P-113 acetate is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5, shows good safety and efficacy profiles in gingivitis and human immunodeficiency virus (HIV) patients with oral candidia...		HIV Protease , Antibacterial , Antibiotic
T3360	ZK 756326	ZK756326 2HCl	CCR
	ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and shows higher 28-fold selectivity over 26 other GPCRs (less ...		CCR
T29037	UC-781	NSC 675186,UC781,UC 781	Antiviral , HIV Protease
	UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resis...		Antiviral , HIV Protease
T4S0797	Berberine	Berberin,Umbellatine	Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy
	1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3....
T0825	Ebselen	SPI-1005,PZ-51,CCG-39161	Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease
	Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b...
T11549	Helioxanthin 8-1	Helioxanthin analogue 8-1	Others
	Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM.		Others
T72203	Reverse transcriptase-IN-3
	Reverse transcriptase-IN-3, a pyrimidine-5-carboxamide derivative, functions as an inhibitor of HIV-1, demonstrating potent activity against both wild-type and mutant strains of HIV-1.
T72162	HIV-1 integrase inhibitor 10
	HIV-1 Integrase Inhibitor 10, an orally active allosteric integrase inhibitor (ALLINI), effectively inhibits the NLRepRluc virus's viral outgrowth in MT-2 cells, exhibiting EC50 values of 3-5 nM. This compound is utilize...
TN2951	3-(hydroxymethyl)cyclopentanone		CCR
	3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the preparation of HIV chemokine CCR-5 receptor antagonists.		CCR
T74488	HIV-1 protease-IN-4
	HIV-1 protease-IN-4 (Compound II-22), a potent inhibitor of the HIV-1 protease, acts as a prodrug for atazanavir. It notably enhances the bioavailability of atazanavir in rat plasma, achieving a 5-fold increase in the ar...
T28494	R-82913	NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib
	R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 ...
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone		HIV Protease , Topoisomerase
	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptas...		HIV Protease , Topoisomerase
FL0097	Beta-L-D4A	2'3'-didehydro-2'3'-dideoxyadenosine
	beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. The biological activity of beta-L-D4A is connected with the termination of the DNA chain synthesis in the 5'-3' direction.
T83837	Rp-Thymidine-5'-O-(1-thiotriphosphate) sodium	Rp-dTTP-α-S
	Rp-Thymidine-5'-O-(1-thiotriphosphate) (Rp-TTP-α-S), an isomer of the sulfur-containing nucleotide derivative TTP-α-S, selectively interacts with HIV-1 reverse transcriptase, exhibiting dissociation constants (Kds) of 45...
TN3152	6-Acetonyldihydrochelerythrine		ERK , BCL , Akt , HIV Protease , PPAR , p53
	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively...		ERK , BCL , Akt , HIV Protease , PPAR , p53
T37874	Feglymycin
	Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities. It is active against Gram-positive bacteria (MICs = 32-64 μg/ml) and inhibits HIV viral replica...
T69081	KRH-1636
	KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell ...