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UC-781

Catalog No. T29037 CAS 178870-32-1

Synonyms: NSC 675186, UC781, UC 781

UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resistance.UC-781 is in a stable state, and is unaffected by lower pH or varying temperatures.

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UC-781, CAS 178870-32-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 191.00
5 mg	In stock	$ 480.00
25 mg	6-8 weeks	$ 1,130.00
50 mg	6-8 weeks	$ 1,480.00

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Purity: 92.17%

Biological Description

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Description	UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resistance.UC-781 is in a stable state, and is unaffected by lower pH or varying temperatures.
Targets&IC50	HIV-1:0.005 μM
In vitro	UC-781 (0.05, 0.2, and 0.5 % UC-781 supplemented gel; 10 days) is released from the gel formulation and clears HIV-1 from CEM cells [1]. UC-781 (3.75 -30 μM) inhibits the growth of Bacillus cereus (approximately 50%).[1] UC-781 inhibits HIV-1 (IIIB) activity in CEM T cells (EC50=6 nM; IC50=23 nM). UC-781 inhibits HIV activity in monocyte-derived dendritic cells (MO-DCs) and autologous CD4+ T cells with EC50 values of 550 nM and 1588 nM, respectively.[2] UC-781 (1000 nM; 24 h) effectively prevents or blocks HIV infection of monocyte-derived dendritic cells and autologous CD4+ T cells.[2] UC-781 (0.001-1000 µM; 2 h) inhibits viral transfer and infection of cervical explants with HIV-1BaL.[4]
In vivo	UC-781 (100 µl 5% UC-781 supplemented gel; intravaginally; once daily for 10 days; Female rabbit) is released from the gel formulation and shows low toxicity to normal tissues in female rabbits and without significant increases in inflammatory cells.[1]

Synonyms	NSC 675186, UC781, UC 781
Molecular Weight	335.85
Formula	C17H18ClNO2S
CAS No.	178870-32-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Balzarini J, et al. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. AIDS. 1998;12(10):1129-1138. 2. Van Herrewege Y, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004;48(1):337-339. 3. Balzarini J, et al. Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. Mol Pharmacol. 1996;50(2):394-401. 4. Fletcher P, et al. The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. J Virol. 2005;79(17):11179-11186.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Anti-Viral Compound Library Bioactive Compounds Library Max Clinical Compound Library Bioactive Compound Library

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Keywords

UC-781 178870-32-1 Immunology/Inflammation Microbiology/Virology Proteases/Proteasome HIV Protease Antiviral NSC 675186 NSC675186 UC781 UC 781 NSC-675186 inhibitor inhibit

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