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Search Result

Search Results for " bd1 "

Targets

Epigenetic Reader Domain

83

Compounds

1

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T64117 BRD4-BD1-IN-2 Epigenetic Reader Domain
BRD4-BD1-IN-2 is a selective and potent BRD4-BD1 inhibitor with an IC50 value of 2.51 µM, which is 20-fold greater than the inhibitory activity against BRD4-BD2.BRD4-BD1-IN-2 can be used in the study of cardiovascular an...
T69506 DBRD4-BD1
dBRD4-BD1 is a selective BRD4 bromodomain inhibitor. dBRD4-BD1 can selectively degrade BRD4 (DC50 = 280 nM). Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BR...
T73296 IBRD4-BD1
iBRD4-BD1 is a selective inhibitor of the BRD4 bromodomain, exhibiting inhibition activity with an IC50 value of 12 nM. It is utilized in the research of inflammation and oncology.
T62030 BRD4-BD1-IN-1
BRD4-BD1-IN-1 (Compound 9a) is a BRD4-BD1 inhibitor(IC50= 38.20 μM).
T63707 BRD4-BD1/2-IN-2
BRD4-BD1/2-IN-2 is a potent inhibitor of BRD4-BD2, capable of acting on both BRD4 BD2 (IC50<0.5 nM) and BRD4 BD1 (IC50<300 nM).
T61791 BRD4-BD1/2-IN-1
BRD4-BD1/2-IN-1 is a highly effective inhibitor of BRD4, specifically targeting the BRD4 BD-1 and BRD4 BD-2 domains with IC 50 values of <100 nM each (US20150148375A1, compound 5) [1].
T9703 GSK778 Epigenetic Reader Domain
GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 (IC50s = 143 nM). GSK778 inhibits proliferation, induces a ...
T60072 ZL0590 Epigenetic Reader Domain
ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.
T7488 BD1063 dhydrochloride BD1063 Sigma receptor
BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
T82541 D-JBD19 TFA
D-JBD19 TFA is a non-permeable peptide [1] that exhibits neuroprotective effects [2].
T62603 NVP-BBD130
NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.
TP2162L D-JBD19 TFA (954134-42-0 free base) D-JBD19 TFA Others
D-JBD19 TFA is a non-permeable peptide with neuroprotective effects.
TP2162 D-JBD19 Others
D-JBD19 is a non-permeable peptide with neuroprotective effects.
T14776 BRD4 Inhibitor-10 Epigenetic Reader Domain
BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
T22345 INCB054329 INCB-054329,INCB-54329,INCB-54329 Epigenetic Reader Domain
INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2 with IC50 values of 44 nM, 5 nM, 9 nM, ...
TQ0253 PLX51107 Epigenetic Reader Domain
PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
T12112 MS402 Epigenetic Reader Domain
MS402 is a novel BD1-selective BET BrD inhibitor.
T13392 ZEN-3219 Others , Epigenetic Reader Domain
ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2). ZEN-3219 has inhibitory effect on BRD4(BD1), The IC50 values of BRD4(BD2) and BRD4(BD1BD2) were 0.48, 0.16 and 0.47 μM, r...
T70375 ZEN-2759 Epigenetic Reader Domain
ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).
T13393 ZEN-3411 Epigenetic Reader Domain
ZEN-3411 is an orally available and potent BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproducing BET proteins.
T10638 BY27 Epigenetic Reader Domain
BY27 is a potent and selective BET BD2 inhibitor (Ki: 3.1 nM) with anticancer activity, inhibits BD1/BD2 of BRD2, BRD3, BRD4 and BRDT, and suppresses tumor growth.
T13394 ZEN-3862 ZEN3862,ZEN 3862 Epigenetic Reader Domain
ZEN-3862 (Willardiine) is an inhibitor of BET(IC50s of 0.16 and 0.13 μM for BRD4(BD1) and BRD4(BD2) , respectively). ZEN-3862 can be used to form PROTACs to induce degradation of BRD4.
T9703L GSK778 hydrochloride Epigenetic Reader Domain
GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 ...
T78555 BRD4 Inhibitor-27 Epigenetic Reader Domain
BRD4 Inhibitor-27 is a potent BRD4 inhibitor that inhibits BRD4 BD1 and BRD4 BD2 with IC50s of 9.6 and 11.3 μM, respectively.BRD4 Inhibitor-27 has anticancer activity and can be used for breast cancer research.
T10773 CF53 Epigenetic Reader Domain , CDK
CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT B...
T16154 MS417 GTPL7512 Epigenetic Reader Domain , HIV Protease
MS417 (GTPL7512) is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP BRD with IC50 of 32.7 μM.
T6828 ZL0420 Epigenetic Reader Domain
ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with nanomolar binding affinities to bromodomains (BDs) of BRD4. ZL0420 has IC 50 values of 27 nM against BRD4 BD1 and 32 nM against B...
T9619 I-BET567
I-BET567, a potent pan-BET inhibitor with oral activity, demonstrates pIC50 values of 6.9 and 7.2 for BRD4 BD1 and BD2, respectively. This compound has exhibited efficacy in mouse models of oncology and inflammation [1].
T5434 ARV-825 Epigenetic Reader Domain
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested.
T10520 BET-IN-2 Epigenetic Reader Domain
BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).
T11887 LT052 Epigenetic Reader Domain
LT052, a highly active and selective BET BD1 inhibitor with an IC50 of 87.7 nM, demonstrates nanomolar BRD4 BD1 potency and significant selectivity, being 138-fold more selective for BRD4 BD1 over BRD4 BD2 (IC50 =12.130 ...
T16701 QCA570 Others
QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).
T28628 RVX-297 RVX297 Epigenetic Reader Domain
RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein.
T5440 Dbet57 Epigenetic Reader Domain
dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2
T78682 SJ1461 Epigenetic Reader Domain
SJ1461 is a potent, orally active inhibitor of the BET family, selectively targeting and inhibiting BRD2 (BD1), BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with respective IC50 values of 1.6 nM, 0.1 nM, 6.5 nM, and 0.2 nM [1]...
T12113 MS645 Epigenetic Reader Domain
MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.
T17294 ZL0454 Epigenetic Reader Domain
ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
T15484 HJB97 Epigenetic Reader Domain
HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2...
T5436 MZ 1 Epigenetic Reader Domain
MZ 1 is a BRD4 protein degrader based on PROTAC technology.
T15443 GSK8814 Epigenetic Reader Domain
GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan). GSK8814 displays 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 binds to ATAD2 an...
T13833 PROTAC BRD4 Degrader-1 Epigenetic Reader Domain
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
T14910 CD161 NKR-P1A Others
CD161 is a potent, selective, and orally bioavailable BET bromodomain inhibitor (IC50s: 28.2 nM and 7.2 nM for BRD4 BD1 and BRD4 BD2) with good anticancer activity.
T13834 PROTAC BRD4 Degrader-2 Epigenetic Reader Domain
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
T63858 I-BET282E
I-BET282E is a pan-inhibitor of eight BET bromodomains and shows selectivity for other representative bromodomain-containing proteins. i-BET282E is able to act on eight BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), BRD4 ...
T12798 (S)-GNE-987 Epigenetic Reader Domain
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
T15419 GS-626510 Epigenetic Reader Domain
GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).
T78851 BRD4 Inhibitor-28 Epigenetic Reader Domain
BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55 nM, respectively. It also demonstrates inhibition of BRD2-BD...
T79167 BET-IN-15 Epigenetic Reader Domain
BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2. It exhibits antiproliferative activity [1].
T61318 BRD4 Inhibitor-20 Epigenetic Reader Domain
BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon canc...
T69588 GSK789
GSK789 is a selective inhibitor of the first bromodomains (BD1) of the bromo and extra terminal domain (BET) proteins.

Compounds

BRD4-BD1-IN-2
T64117
Synonym:
Target: Epigenetic Reader Domain
dBRD4-BD1
T69506
Synonym:
Target:
iBRD4-BD1
T73296
Synonym:
Target:
BRD4-BD1-IN-1
T62030
Synonym:
Target:
BRD4-BD1/2-IN-2
T63707
Synonym:
Target:
BRD4-BD1/2-IN-1
T61791
Synonym:
Target:
GSK778
T9703
Synonym:
Target: Epigenetic Reader Domain
ZL0590
T60072
Synonym:
Target: Epigenetic Reader Domain
BD1063 dhydrochloride
T7488
Synonym: BD1063
Target: Sigma receptor
D-JBD19 TFA
T82541
Synonym:
Target:
NVP-BBD130
T62603
Synonym:
Target:
D-JBD19 TFA (954134-42-0 free base)
TP2162L
Synonym: D-JBD19 TFA
Target: Others
D-JBD19
TP2162
Synonym:
Target: Others
BRD4 Inhibitor-10
T14776
Synonym:
Target: Epigenetic Reader Domain
INCB054329
T22345
Synonym: INCB-054329,INCB-54329,INCB-54329
Target: Epigenetic Reader Domain
PLX51107
TQ0253
Synonym:
Target: Epigenetic Reader Domain
MS402
T12112
Synonym:
Target: Epigenetic Reader Domain
ZEN-3219
T13392
Synonym:
Target: Others, Epigenetic Reader Domain
ZEN-2759
T70375
Synonym:
Target: Epigenetic Reader Domain
ZEN-3411
T13393
Synonym:
Target: Epigenetic Reader Domain
BY27
T10638
Synonym:
Target: Epigenetic Reader Domain
ZEN-3862
T13394
Synonym: ZEN3862,ZEN 3862
Target: Epigenetic Reader Domain
GSK778 hydrochloride
T9703L
Synonym:
Target: Epigenetic Reader Domain
BRD4 Inhibitor-27
T78555
Synonym:
Target: Epigenetic Reader Domain
CF53
T10773
Synonym:
Target: Epigenetic Reader Domain, CDK
MS417
T16154
Synonym: GTPL7512
Target: Epigenetic Reader Domain, HIV Protease
ZL0420
T6828
Synonym:
Target: Epigenetic Reader Domain
I-BET567
T9619
Synonym:
Target:
ARV-825
T5434
Synonym:
Target: Epigenetic Reader Domain
BET-IN-2
T10520
Synonym:
Target: Epigenetic Reader Domain
LT052
T11887
Synonym:
Target: Epigenetic Reader Domain
QCA570
T16701
Synonym:
Target: Others
RVX-297
T28628
Synonym: RVX297
Target: Epigenetic Reader Domain
Dbet57
T5440
Synonym:
Target: Epigenetic Reader Domain
SJ1461
T78682
Synonym:
Target: Epigenetic Reader Domain
MS645
T12113
Synonym:
Target: Epigenetic Reader Domain
ZL0454
T17294
Synonym:
Target: Epigenetic Reader Domain
HJB97
T15484
Synonym:
Target: Epigenetic Reader Domain
MZ 1
T5436
Synonym:
Target: Epigenetic Reader Domain
GSK8814
T15443
Synonym:
Target: Epigenetic Reader Domain
PROTAC BRD4 Degrader-1
T13833
Synonym:
Target: Epigenetic Reader Domain
CD161
T14910
Synonym: NKR-P1A
Target: Others
PROTAC BRD4 Degrader-2
T13834
Synonym:
Target: Epigenetic Reader Domain
I-BET282E
T63858
Synonym:
Target:
(S)-GNE-987
T12798
Synonym:
Target: Epigenetic Reader Domain
GS-626510
T15419
Synonym:
Target: Epigenetic Reader Domain
BRD4 Inhibitor-28
T78851
Synonym:
Target: Epigenetic Reader Domain
BET-IN-15
T79167
Synonym:
Target: Epigenetic Reader Domain
BRD4 Inhibitor-20
T61318
Synonym:
Target: Epigenetic Reader Domain
GSK789
T69588
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
TN1973 Naringenin triacetate Others
Naringenin triacetate exhibits a better binding affinity with multiple crystal structures of first bromodomain BRD4 (BRD4 BD1) when compared with the known inhibitors.

Natural Products

Naringenin triacetate
TN1973
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (2)
Expression System：
E. coli (1)
HEK293 Cells (1)
Tag：
C-hFc (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPY-04170 DEFB1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
The DEFB1 gene, encoding for the constitutively expressed human beta-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been rep...
TMPJ-00003 DEFB1 Protein, Human, Recombinant Human E. coli
β-Defensin 1 (DEFB1) is a member of the β-defensin family, which is highly expressed by epithelial cells. β-defensins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a si...
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