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Search Results for " antifolate "

20

Compounds

Cat No. Product Name Synonyms Targets
T26636 Antifolate C2 AGF 154,AGF154,AGF-154 Others
Antifolate C2 (AGF 154) has antitumor activity with an IC of 0.14 nM measured in a growth inhibition assay of human tumor cells.Antifolate C2 can be used for the study of cancer and autoimmune diseases.
T26635 Antifolate C1 AGF 94,AGF94,AGF-94
Antifolate C1 is an inhibitor of de novo purine biosynthesis. Antifolate C1 has selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter (PCFT) over the reduced folate c...
T36692 Fanotaprim DHFR
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o...
T8548 Metoprine Histone Methyltransferase , Antifolate , Histamine Receptor
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
T16045 Methotrexate metabolite DAMPA Antifolate , Drug Metabolite
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant.
T7593 Levomefolate calcium Antifolate
Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.
T7730 Aminopterin APGA,4-Aminofolic acid Antifolate
Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase
T8003 Methotrexate disodium Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
T6431 Levoleucovorin Calcium Calcium Levofolinate,CL307782 Others , Antifolate
Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.
T4382 Proguanil hydrochloride Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil Others , Dehydrogenase , DNA/RNA Synthesis , Antifolate , Parasite
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ...
T0849 Pyrimethamine Pirimecidan,RP 4753,Pirimetamin DHFR , Antifolate , Parasite
Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
T3693 DHFR-IN-3 7-bromoquinazoline-2,4-diamine Others
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.
T0148 Folinic acid calcium Wellcovorin,Calcium folinate,Leucovorin Calcium,Folinic acid calcium salt DNA/RNA Synthesis , Endogenous Metabolite , Antifolate
Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
T0189L Pemetrexed disodium LY-231514,LY231514 disodium,Pemetrexed Apoptosis , DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
Pemetrexed disodium (LY-231514) is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothelioma. Pemetrexed disodium therapy has b...
T2204 Diaveridine EGIS-5645,CCRIS-3784,AI3-23935 DHFR , Antifolate , Antibacterial
Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cells, but more studies are required to clarify th...
T7598 Calcium N5-methyltetrahydrofolate NSC173328 Others , Antifolate
Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers
T0189 Pemetrexed Pemetrexed acid,LY231514,LY-231514 Disodium Hydrate DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
T6120 Pralatrexate Folotyn,10-Propargyl-10-deazaaminopterin Apoptosis , DHFR , Antifolate , TAM Receptor
Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act...
T17257 WR99210 DHFR , Antifolate , Antibacterial
WR99210 is a potent, orally available and less toxic dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 has good antiparasitic activity against P. vivax and P. falciparum strains (including P. falciparum s...
T1153 Trimethoprim NIH 204,BW 56-72,NSC-106568 DHFR , DNA/RNA Synthesis , Antifolate , Antibacterial , Antibiotic
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Tra...

Compounds

Antifolate C2
T26636
Synonym: AGF 154,AGF154,AGF-154
Target: Others
Antifolate C1
T26635
Synonym: AGF 94,AGF94,AGF-94
Target:
Fanotaprim
T36692
Synonym:
Target: DHFR
Metoprine
T8548
Synonym:
Target: Histone Methyltransferase, Antifolate, Histamine Receptor
Methotrexate metabolite
T16045
Synonym: DAMPA
Target: Antifolate, Drug Metabolite
Levomefolate calcium
T7593
Synonym:
Target: Antifolate
Aminopterin
T7730
Synonym: APGA,4-Aminofolic acid
Target: Antifolate
Methotrexate disodium
T8003
Synonym:
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
Levoleucovorin Calcium
T6431
Synonym: Calcium Levofolinate,CL307782
Target: Others, Antifolate
Proguanil hydrochloride
T4382
Synonym: Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil
Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite
Pyrimethamine
T0849
Synonym: Pirimecidan,RP 4753,Pirimetamin
Target: DHFR, Antifolate, Parasite
DHFR-IN-3
T3693
Synonym: 7-bromoquinazoline-2,4-diamine
Target: Others
Folinic acid calcium
T0148
Synonym: Wellcovorin,Calcium folinate,Leucovorin Calcium,Folinic acid calcium salt
Target: DNA/RNA Synthesis, Endogenous Metabolite, Antifolate
Pemetrexed disodium
T0189L
Synonym: LY-231514,LY231514 disodium,Pemetrexed
Target: Apoptosis, DHFR, DNA/RNA Synthesis, Antifolate, Autophagy
Diaveridine
T2204
Synonym: EGIS-5645,CCRIS-3784,AI3-23935
Target: DHFR, Antifolate, Antibacterial
Calcium N5-methyltetrahydrofolate
T7598
Synonym: NSC173328
Target: Others, Antifolate
Pemetrexed
T0189
Synonym: Pemetrexed acid,LY231514,LY-231514 Disodium Hydrate
Target: DHFR, DNA/RNA Synthesis, Antifolate, Autophagy
Pralatrexate
T6120
Synonym: Folotyn,10-Propargyl-10-deazaaminopterin
Target: Apoptosis, DHFR, Antifolate, TAM Receptor
WR99210
T17257
Synonym:
Target: DHFR, Antifolate, Antibacterial
Trimethoprim
T1153
Synonym: NIH 204,BW 56-72,NSC-106568
Target: DHFR, DNA/RNA Synthesis, Antifolate, Antibacterial, Antibiotic
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TargetMol