20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T26636 | Antifolate C2 | AGF 154,AGF154,AGF-154 | Others |
Antifolate C2 (AGF 154) has antitumor activity with an IC of 0.14 nM measured in a growth inhibition assay of human tumor cells.Antifolate C2 can be used for the study of cancer and autoimmune diseases. | |||
T26635 | Antifolate C1 | AGF 94,AGF94,AGF-94 | |
Antifolate C1 is an inhibitor of de novo purine biosynthesis. Antifolate C1 has selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter (PCFT) over the reduced folate c... | |||
T36692 | Fanotaprim | DHFR | |
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o... | |||
T8548 | Metoprine | Histone Methyltransferase , Antifolate , Histamine Receptor | |
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity. | |||
T16045 | Methotrexate metabolite | DAMPA | Antifolate , Drug Metabolite |
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. | |||
T7593 | Levomefolate calcium | Antifolate | |
Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements. | |||
T7730 | Aminopterin | APGA,4-Aminofolic acid | Antifolate |
Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase | |||
T8003 | Methotrexate disodium | Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate | |
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor | |||
T6431 | Levoleucovorin Calcium | Calcium Levofolinate,CL307782 | Others , Antifolate |
Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant. | |||
T4382 | Proguanil hydrochloride | Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil | Others , Dehydrogenase , DNA/RNA Synthesis , Antifolate , Parasite |
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ... | |||
T0849 | Pyrimethamine | Pirimecidan,RP 4753,Pirimetamin | DHFR , Antifolate , Parasite |
Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug. | |||
T3693 | DHFR-IN-3 | 7-bromoquinazoline-2,4-diamine | Others |
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical. | |||
T0148 | Folinic acid calcium | Wellcovorin,Calcium folinate,Leucovorin Calcium,Folinic acid calcium salt | DNA/RNA Synthesis , Endogenous Metabolite , Antifolate |
Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists. | |||
T0189L | Pemetrexed disodium | LY-231514,LY231514 disodium,Pemetrexed | Apoptosis , DHFR , DNA/RNA Synthesis , Antifolate , Autophagy |
Pemetrexed disodium (LY-231514) is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothelioma. Pemetrexed disodium therapy has b... | |||
T2204 | Diaveridine | EGIS-5645,CCRIS-3784,AI3-23935 | DHFR , Antifolate , Antibacterial |
Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cells, but more studies are required to clarify th... | |||
T7598 | Calcium N5-methyltetrahydrofolate | NSC173328 | Others , Antifolate |
Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers | |||
T0189 | Pemetrexed | Pemetrexed acid,LY231514,LY-231514 Disodium Hydrate | DHFR , DNA/RNA Synthesis , Antifolate , Autophagy |
Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS). | |||
T6120 | Pralatrexate | Folotyn,10-Propargyl-10-deazaaminopterin | Apoptosis , DHFR , Antifolate , TAM Receptor |
Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act... | |||
T17257 | WR99210 | DHFR , Antifolate , Antibacterial | |
WR99210 is a potent, orally available and less toxic dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 has good antiparasitic activity against P. vivax and P. falciparum strains (including P. falciparum s... | |||
T1153 | Trimethoprim | NIH 204,BW 56-72,NSC-106568 | DHFR , DNA/RNA Synthesis , Antifolate , Antibacterial , Antibiotic |
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Tra... |