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Catalog No. T6120   CAS 146464-95-1
Synonyms: Folotyn, 10-Propargyl-10-deazaaminopterin

Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.

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Pralatrexate Chemical Structure
Pralatrexate, CAS 146464-95-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 30.00
2 mg In stock $ 44.00
5 mg In stock $ 68.00
10 mg In stock $ 117.00
25 mg In stock $ 172.00
50 mg In stock $ 207.00
100 mg In stock $ 369.00
1 mL * 10 mM (in DMSO) In stock $ 72.00
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Purity: 98.56%
Purity: 98.12%
Purity: 94.32%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.
Targets&IC50 Axl (SUM149 cells):0.43 μM, Axl (KPL-4 cells):0.16 μM
In vitro Pralatrexate and bortezomib exhibits concentration- and time-dependent cytotoxicity against a broad panel of T-lymphoma cell lines. Pralatrexate shows synergism when combined with bortezomib in all cell lines studied. Pralatrexate also induces potent apoptosis and caspase activation when combined with bortezomib across the panel. Pralatrexate significantly modulates the expression of p27, NOXA, HH3, and RFC-1 as assessed by Western blot assays. [1] Pralatrexate is rationally designed for improved cellular transport via RFC-1, and to have greater intracellular drug retention through the enhanced formation of polyglutamylated conjugates. Pralatrexate is thought to exert its pharmacological effect primarily through inhibition of DHFR, having an IC50 in the picomolar range. [2] Pralatrexate demonstrates superior intracellular transport via the reduced folate carrier, and increased accumulation within cells by enhanced polyglutamylation. Pralatrexate exhibits antitumor activity that is superior to the activity of other antifolates. [3] Pralatrexate's enhanced activity relative to methotrexate (MTX) is due to its much more rapid rate of transport and polyglutamation, the former less important when the carrier is saturated. [4]
In vivo Pralatrexate treatment results in treatment-related toxicity in MV522 mice models, as determined by significant weight loss in some animals prior to death; however, remaining mice regains all lost weight by Day 35. [2]
Synonyms Folotyn, 10-Propargyl-10-deazaaminopterin
Molecular Weight 477.47
Formula C23H23N7O5
CAS No. 146464-95-1


store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27 mg/mL (56.5 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Marchi E, et al. Clin Cancer Res, 2010, 16(14), 3648-3658. 2. Izbicka E, et al. Cancer Chemother Pharmacol, 2009, 64(5), 993-999. 3. Molina JR, et al. IDrugs, 2008, 11(7), 508-521. 4. Visentin M, et al. Cancer Chemother Pharmacol, 2013, 72(3), 597-606.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Tyrosine Kinase Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Kinase Inhibitor Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library EMA Approved Drug Library FDA-Approved Kinase Inhibitor Library Inhibitor Library

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Pralatrexate 146464-95-1 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Tyrosine Kinase/Adaptors Antifolate TAM Receptor DHFR antitumor folylpolyglutamate Folotyn cytotoxicity inhibit Inhibitor RFC-1 dihydrofolate p27 reductase synthetase 10-Propargyl-10-deazaaminopterin inhibitor