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Trimethoprim
🥰Excellent
Catalog No. T1153Cas No. 738-70-5
Alias NSC-106568, NIH 204, BW 56-72
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
Trimethoprim
🥰Excellent
Purity: 99.81%
Catalog No. T1153Alias NSC-106568, NIH 204, BW 56-72Cas No. 738-70-5
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $45 | In Stock |
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Purity:99.81%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor. |
| In vivo | Trimethoprim acts by interfering with the bacterial dihydrofolate reductase, inhibiting the synthesis of tetrahydrofolic acid. This inhibition causes a deficiency in nucleotides essential for bacterial DNA replication, which in some instances leads to cell death due to thymineless death. |
| Alias | NSC-106568, NIH 204, BW 56-72 |
| Molecular Weight | 290.32 |
| Formula | C14H18N4O3 |
| Cas No. | 738-70-5 |
| Smiles | COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC |
| Relative Density. | 1.1648 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (189.45 mM), Sonication is recommended.  Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
urinary tract infectionsTrimethoprimThymidylate synthasetetrahydrofolateShigellosisRNASynthesisRNA SynthesisreductaseproteinPneumocystis pneumoniaNSC106568NSC 106568NIH-204NIH204metabolismInhibitorinhibitInfluenza VirusHspsfolateDNASynthesisDNA SynthesisdihydrofolateDHFRBacterialAntimicrobialAntifolateAntibioticaggregation
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