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Trimethoprim

Trimethoprim
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Purity:99.88%
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Trimethoprim

Catalog No. T1153Cas No. 738-70-5
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
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500 mg$45In Stock
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Product Introduction

Bioactivity
Description
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
In vivo
Trimethoprim acts by interfering with the bacterial dihydrofolate reductase, inhibiting the synthesis of tetrahydrofolic acid. This inhibition causes a deficiency in nucleotides essential for bacterial DNA replication, which in some instances leads to cell death due to thymineless death.
AliasNIH 204, BW 56-72, NSC-106568
Chemical Properties
Molecular Weight290.32
FormulaC14H18N4O3
Cas No.738-70-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 55 mg/mL (189.45 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4445 mL17.2224 mL34.4448 mL172.2238 mL
5 mM0.6889 mL3.4445 mL6.8890 mL34.4448 mL
10 mM0.3444 mL1.7222 mL3.4445 mL17.2224 mL
20 mM0.1722 mL0.8611 mL1.7222 mL8.6112 mL
50 mM0.0689 mL0.3444 mL0.6889 mL3.4445 mL
100 mM0.0344 mL0.1722 mL0.3444 mL1.7222 mL

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