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Trimethoprim

Catalog No. T1153 CAS 738-70-5

Synonyms: 甲氧苄啶, NSC-106568, BW 56-72, NIH 204

Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.

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Trimethoprim, CAS 738-70-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	甲氧苄啶, NSC-106568, BW 56-72, NIH 204
Molecular Weight	290.323
Formula	C14H18N4O3
CAS No.	738-70-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 54 mg/mL (186 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Vouloumanou EK, et al. Int J Antimicrob Agents, 2011, 38(3), 197-216. 2. Cribb AE, et al. Adverse Drug React Toxicol Rev, 1996, 15(1), 9-50.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Antibiotics Library Inhibitor Library DNA Damage & Repair Compound Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Cell Cycle Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library

Related Products

Related compounds with same targets

Protoanemonin (-)-α-Pinene Nanchangmycin Amikacin hydrate Sulfaclozine sodium Lenampicillin hydrochloride Cephradine monohydrate Cefodizime

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Mass of a compound required to prepare a solution of known volume and concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Trimethoprim 738-70-5 DNA损伤和修复代谢微生物学细胞周期 Antibacterial Antibiotic Antifolate DHFR DNA/RNA Synthesis Inhibitor Shigellosis folate inhibit Hsps protein urinary tract infections reductase Pneumocystis pneumonia Influenza Virus Bacterial NIH 204 aggregation BW 56-72 NSC-106568 metabolism tetrahydrofolate dihydrofolate Antimicrobial inhibitor

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