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Proguanil hydrochloride

Proguanil hydrochloride
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Purity:98.34%
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Proguanil hydrochloride

Catalog No. T4382Cas No. 637-32-1
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
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Pack SizePrice/USDAvailabilityQuantity
5 mg$50In Stock
10 mg$60In Stock
25 mg$102In Stock
50 mg$190In Stock
100 mg$340In Stock
200 mg$545In Stock
500 mg$878In Stock
1 mL x 10 mM (in DMSO)$64In Stock
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Product Introduction

Bioactivity
Description
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
In vitro
proguanil appeared to be a substrate of OCT1 and OCT2 with affinities of 8.1 and 9.0 μM, respectively
Cell Research
Sertoli cells obtained from sixteen to eighteen day-old-rats are cultured and treated with 0.3 μM to 10 μM of proguanil for 5 days after which Sertoli cell viability and nuclei integrity are determined. Also, the genetic expressions of transferrin and Glial cell line-derived neurotrophic factor are assessed. They are for reference only.
Animal Research
Proguanil is prepared in distilled water.Rats: Groups of ten to twelve-week-old rats are administered proguanil (2.9 mg/kg body weight) daily for 5 days and 6 weeks respectively. Thereafter, body and reproductive organ weights are taken, sperm parameters are analyzed, while the histology of the testis and epididymis are carried out. Also, serum levels of testosterone, luteinizing hormone and follicle stimulating hormone are determined. They are for reference only.
AliasPaludrine hydrochloride, Chlorguanide hydrochloride, Chloroquanil
Chemical Properties
Molecular Weight290.19
FormulaC11H17Cl2N5
Cas No.637-32-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 55 mg/mL (189.53 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4460 mL17.2301 mL34.4602 mL172.3009 mL
5 mM0.6892 mL3.4460 mL6.8920 mL34.4602 mL
10 mM0.3446 mL1.7230 mL3.4460 mL17.2301 mL
20 mM0.1723 mL0.8615 mL1.7230 mL8.6150 mL
50 mM0.0689 mL0.3446 mL0.6892 mL3.4460 mL
100 mM0.0345 mL0.1723 mL0.3446 mL1.7230 mL

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Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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