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Proguanil hydrochloride

Catalog No. T4382 CAS 637-32-1

Synonyms: Paludrine hydrochloride, 盐酸氯胍, Chlorguanide hydrochloride, Chloroquanil

Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.

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Proguanil hydrochloride, CAS 637-32-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
In vitro	proguanil appeared to be a substrate of OCT1 and OCT2 with affinities of 8.1 and 9.0 μM, respectively
Cell Research	Sertoli cells obtained from sixteen to eighteen day-old-rats are cultured and treated with 0.3 μM to 10 μM of proguanil for 5 days after which Sertoli cell viability and nuclei integrity are determined. Also, the genetic expressions of transferrin and Glial cell line-derived neurotrophic factor are assessed. They are for reference only.
Animal Research	Proguanil is prepared in distilled water.Rats: Groups of ten to twelve-week-old rats are administered proguanil (2.9 mg/kg body weight) daily for 5 days and 6 weeks respectively. Thereafter, body and reproductive organ weights are taken, sperm parameters are analyzed, while the histology of the testis and epididymis are carried out. Also, serum levels of testosterone, luteinizing hormone and follicle stimulating hormone are determined. They are for reference only.

Synonyms	Paludrine hydrochloride, 盐酸氯胍, Chlorguanide hydrochloride, Chloroquanil
Molecular Weight	290.19
Formula	C11H17Cl2N5
CAS No.	637-32-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gerlinde F. Plöger, etal. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride[J]. Journal of Pharmaceutical Sciences, 2018, 163(4):1-21.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library DNA Damage & Repair Compound Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library Toxic Compound Library Approved Drug Library

Related Products

Related compounds with same targets

Metoprine Aminopterin Calcium N5-methyltetrahydrofolate Levomefolate calcium Pemetrexed disodium hemipenta hydrate Pralatrexate Proguanil hydrochloride Diaveridine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Proguanil hydrochloride 637-32-1 DNA损伤和修复代谢其他微生物学细胞周期 Antifolate Dehydrogenase DNA/RNA Synthesis Others Parasite Proguanil infection biguanide Inhibitor embryotoxicity toxicity inhibit Chlorguanide hydrochloride reproductive Paludrine hydrochloride antimalarial Chloroquanil inhibitor

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