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Proguanil hydrochloride

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Purity:98.34%

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COA HNMR LCMS

Proguanil hydrochloride

Catalog No. T4382Cas No. 637-32-1

Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.

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Pack Size	Price	Availability
5 mg	$50	In Stock
10 mg	$60	In Stock
25 mg	$102	In Stock
50 mg	$190	In Stock
100 mg	$340	In Stock
200 mg	$545	In Stock
500 mg	$878	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock

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Product Introduction

Bioactivity

Description	Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
In vitro	proguanil appeared to be a substrate of OCT1 and OCT2 with affinities of 8.1 and 9.0 μM, respectively
Cell Research	Sertoli cells obtained from sixteen to eighteen day-old-rats are cultured and treated with 0.3 μM to 10 μM of proguanil for 5 days after which Sertoli cell viability and nuclei integrity are determined. Also, the genetic expressions of transferrin and Glial cell line-derived neurotrophic factor are assessed. They are for reference only.
Animal Research	Proguanil is prepared in distilled water.Rats: Groups of ten to twelve-week-old rats are administered proguanil (2.9 mg/kg body weight) daily for 5 days and 6 weeks respectively. Thereafter, body and reproductive organ weights are taken, sperm parameters are analyzed, while the histology of the testis and epididymis are carried out. Also, serum levels of testosterone, luteinizing hormone and follicle stimulating hormone are determined. They are for reference only.
Alias	Paludrine hydrochloride, Chlorguanide hydrochloride, Chloroquanil

Chemical Properties

Molecular Weight	290.19
Formula	C11H17Cl2N5
Cas No.	637-32-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (189.53 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4460 mL	17.2301 mL	34.4602 mL	172.3009 mL
5 mM	0.6892 mL	3.4460 mL	6.8920 mL	34.4602 mL
10 mM	0.3446 mL	1.7230 mL	3.4460 mL	17.2301 mL
20 mM	0.1723 mL	0.8615 mL	1.7230 mL	8.6150 mL
50 mM	0.0689 mL	0.3446 mL	0.6892 mL	3.4460 mL
100 mM	0.0345 mL	0.1723 mL	0.3446 mL	1.7230 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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