aldosterone — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T19186	Aldosterone		Others
	Aldosterone is the primary mineralocorticoid. Aldosterone is synthesized and secreted in response to renin-angiotensin system activation or high dietary potassium by the zona glomerulosa of the adrenal cortex.		Others
T19185	Aldosterone-d8	Aldosterone D8	Others
	Aldosterone D8, a deuterium-labeled variant of Aldosterone produced in the adrenal zona glomerulosa, regulates blood pressure.		Others
T36381	Aldosterone 21-sulfate (sodium salt)
	Aldosterone 21-sulfate is a metabolite of the steroid hormone aldosterone .1It reduces the sodium-to-potassium ratio in rat urine when administered at doses ranging from 10 to 100 μg, indicating mineralocorticoid activit...
T29852	Aldosterone-3-(O-carboxymethyl)oximino-(2-iodohistamine)
	Aldosterone-3-(O-carboxymethyl)oximino-(2-iodohistamine) is a biochemical.
T4316	ML365		Potassium Channel
	ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).		Potassium Channel
T0293	Metyrapone	NSC-25265,Su-4885	Others , P450 , Dehydrogenase , Autophagy
	Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.		Others , P450 , Dehydrogenase , Autophagy
T1410	Torsemide	AC-4464,JDL-464,Torasemide	Na-K-Cl cotransporter
	Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h...		Na-K-Cl cotransporter
T0083	Eplerenone	Epoxymexrenone,CGP 30083,SC-66110	Glucocorticoid Receptor
	Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase ...		Glucocorticoid Receptor
T3033	Deoxycorticosterone acetate	DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate	Glucocorticoid Receptor , Endogenous Metabolite , Adrenergic Receptor
	Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid.
T4277	Osilodrostat	LCI699	Glucocorticoid Receptor , Others , Hydroxylase
	Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).		Glucocorticoid Receptor , Others , Hydroxylase
T0354	Canrenone	6,7-Dehydro-7α-desthioacetylspironolactone,SC9376,Aldadiene,RP-11614,SC14266	Glucocorticoid Receptor , Endogenous Metabolite
	Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity.		Glucocorticoid Receptor , Endogenous Metabolite
T0476	Spironolactone	SC9420,Abbolactone	Glucocorticoid Receptor , Androgen Receptor , Autophagy
	Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.		Glucocorticoid Receptor , Androgen Receptor , Autophagy
T13881	Dicirenone	SC26304	ATPase , Glucocorticoid Receptor
	Dicirenone (SC26304) inhibits the Mineralocorticoid receptor (MR), aldosterone regulation of the urinary K+:Na+ ratio, and aldosterone binding to renal cytoplasmic and nuclear receptors.		ATPase , Glucocorticoid Receptor
T61373	Baxdrostat		Others
	Baxdrostat is an aldosterone synthase inhibitor.		Others
T20302	Deoxycorticosterone	Desoxycorticosterone,Desoxycorticosteronum,Desoxycortone	Endogenous Metabolite
	Deoxycorticosterone (Desoxycortone) is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.		Endogenous Metabolite
T71664	Mespirenone		Others
	Mespirenone is a spironolactone derivative and aldosterone antagonist with diuretic effects.		Others
T3096	Canrenoate potassium	Potassium aldadiene,Canrenoic acid potassium salt,Potassium canrenoate,Soldactone	Glucocorticoid Receptor
	Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity.		Glucocorticoid Receptor
T1866	AT-56		Others , PGE Synthase
	AT56, a specific inhibitor of prostaglandin D2 synthase enzymatic activity, blunted adipogenic aldosterone effects.		Others , PGE Synthase
T6262	Evacetrapib	LY2484595	CETP
	Evacetrapib (LY2484595) (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3.		CETP
T7040	Angiotensin II human	DRVYIHPF,Angiotensin II,Hypertensin II,Ang II	Apoptosis , RAAS
	Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthes...		Apoptosis , RAAS