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Angiotensin II human

Catalog No. T7040 CAS 4474-91-3

Synonyms: DRVYIHPF, Angiotensin II, Hypertensin II, Ang II

Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthesis and renal activity in humans.

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Angiotensin II human, CAS 4474-91-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 37.00
10 mg	In stock	$ 59.00
25 mg	In stock	$ 123.00
50 mg	In stock	$ 225.00
100 mg	In stock	$ 321.00
500 mg	In stock	$ 779.00

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Purity: 100%

Purity: 99.86%

Purity: 95%

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Description	Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthesis and renal activity in humans.
In vitro	METHODS: Human hepatocellular carcinoma cells (HCC) HepG-2, SMMC-7721, and MHCC97-H were treated with Angiotensin II (1-1000 nM) for 24-72 h. The cell viability was determined using MTT. RESULTS: Angiotensin II induced HCC cell lines to show higher growth in a time- and concentration-dependent manner. [1] METHODS: Neonatal rat cardiomyocytes were treated with Angiotensin II (1 μmol/L) for 5 min-48 h. HMGB1 and IL-6 expression levels were measured by ELISA and RT-qPCR. RESULTS: Angiotensin II enhanced the expression levels of HMGB1 and IL-6 in cardiomyocytes. [2]
In vivo	METHODS: To determine insulin action in a human hypertensive mouse model, Angiotensin II (1.1 mg/kg in 0.9% saline) was administered to C57Bl/6J mice using an osmotic minipump for two to four weeks. RESULTS: Blood pressure increased after Angiotensin II treatment. The increase in serum insulin was greater in Angiotensin II-treated mice after glucose administration. Long-term Angiotensin II treatment for four weeks enhanced glucose-stimulated insulin secretion in mice. [3] METHODS: To analyze genotoxic effects in vivo, Angiotensin II (60 ng/kg/min-1 μg/kg/min) was administered using an osmotic minipump to C57Bl/6J mice for four weeks. RESULTS: Angiotensin II increased SBP up to 38 mmHg over control and adversely affected renal function in mice. In the heart, a significant increase in reactive oxygen species formation and double-strand breaks were detected at the highest administered dose. In the kidney, a dose-dependent increase in superoxide formation, double-strand breaks and DNA base modification mutations were observed. [4]
Animal Research	(129×C57BL/6) F1 mice, which lack AT1A receptors Angiotensin II used, are fed 10 gm/day gelled 0.25% NaCl diet that contains all nutrients and water. After 28 days of Angiotensin II infusion, hearts are harvested, weighed fixed in formalin, sectioned, and stained with Masson trichrome.

Synonyms	DRVYIHPF, Angiotensin II, Hypertensin II, Ang II
Molecular Weight	1046.18
Formula	C50H71N13O12
CAS No.	4474-91-3

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 1 mg/mL

DMSO: 5 mg/mL(4.77 mM), Sonification is recommended.

References and Literature

1. Ji Y, et al. Angiotensin II Enhances Proliferation and Inflammation through AT1/PKC/NF-κB Signaling Pathway in Hepatocellular Carcinoma Cells. Cell Physiol Biochem. 2016 Jul;39(1):13-32. 2. Zhang L, et al. Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload. Int Heart J. 2021 Jan 30;62(1):162-170. 3. Gletsu N, et al. Angiotensin II-induced hypertension in mice caused an increase in insulin secretion. Vascul Pharmacol. 2005 Feb;42(3):83-92. 4. Brand S, et al. Angiotensin II-induced hypertension dose-dependently leads to oxidative stress and DNA damage in mouse kidneys and hearts. J Hypertens. 2013 Feb;31(2):333-44. 5. Zhang R Y, Wu C M, Hu X M, et al. LncRNA AC105942. 1 Downregulates hnRNPA2/B1 to Attenuate Vascular Smooth Muscle Cells Proliferation[J]. DNA and Cell Biology. 2021

Citations

1. Zhang R Y, Wu C M, Hu X M, et al. LncRNA AC105942. 1 Downregulates hnRNPA2/B1 to Attenuate Vascular Smooth Muscle Cells Proliferation. DNA and Cell Biology. 2021 2. Zhang L, Zhang B, Yu Y, et al. Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload. International Heart Journal. 2021: 20-384

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library NO PAINS Compound Library Apoptosis Compound Library Anti-Cancer Compound Library Endocrinology-Hormone Compound Library FDA-Approved & Pharmacopeia Drug Library

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Keywords

Angiotensin II human 4474-91-3 Apoptosis Endocrinology/Hormones RAAS DRVYIHPF Angiotensin Receptor Inhibitor Angiotensin II Hypertensin II inhibit Ang II inhibitor

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