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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T22223 | 3PO | Glucokinase , Autophagy | |
3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decrea... | |||
T4367 | Mycro 3 | Mycro-3 | c-Myc , Autophagy |
Mycro 3 is potent and selective for c-Myc in whole cell assays. | |||
T8796 | CAN508 | CDK | |
CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50... | |||
T23372 | SMIFH2 | Others | |
SMIFH2 is formin homology 2 (FH2) domains inhibitor. | |||
T8320 | J14 | J-14 | Reactive Oxygen Species |
J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death | |||
T6609 | NMS-E973 | HSP | |
NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases. | |||
T12854 | SBI-797812 | NAMPT | |
SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM). | |||
T8766 | GOT1 inhibitor-1 | GOT1 inhibitor 2c | Others |
GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. | |||
T9891 | PARP1-IN-8 | N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide | PARP |
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM). | |||
T2613 | Almorexant | ACT 078573 | OX Receptor |
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T6155 | Almorexant hydrochloride | ACT-078573 hydrochloride,Almorexant HCl | OX Receptor |
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T1166 | Ellipticine | NSC 71795,Elliptisine | Topoisomerase |
Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-6... | |||
T13111 | Tegadifur | 40497S,FD 1 | Others |
Tegadifur (40497S) is an orally available antitumor compound with antimetabolic effects, often used with uracil and in the treatment of rectal adenocarcinoma. | |||
T36115 | Colchicoside | 3-Demethylcolchicine glucoside | Others |
Colchicoside (3-Demethylcolchicine glucoside) is extracted from Gloriosa superba and shows efficacy in a murine model of pancreatic adenocarcinoma. | |||
T3786 | Tomatine | lycopersicin | Apoptosis , Proteasome |
Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells. | |||
TNU0031 | 5-Hydroxyuridine | OHUrd | Nucleoside Antimetabolite/Analog |
5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue with potential antitumour activity, showing cytotoxicity against human colon adenocarcinoma cell lines. | |||
TN2430 | Glucodigifucoside | ||
Glucodigifucoside, a cardiac glycoside that can be isolated from digitalis seeds, is specifically cytotoxic to human renal adenocarcinoma cells. | |||
T35673 | Stictic Acid | Scopularic acid | Others |
Stictic Acid (Scopularic acid) is isolated from a Sumatran lichen Stereocaulon montagneanum and inhibits the growth of HT-29 human colon adenocarcinoma cells with an IC50 of 29.29 μg/ml. | |||
T15558 | GSK319347A | IκB/IKK | |
GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma. | |||
T5753 | Flavokawain C | Apoptosis | |
Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the treatment of colon adenocarcinoma. |