543 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15143	DMP-543	XR-543	Others , Potassium Channel
	DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters.		Others , Potassium Channel
T8840	PF-543 hydrochloride	PF-543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T6085	PF-543	Sphingosine Kinase 1 Inhibitor II,PF 543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T29188	YM-543 trimethylamine	ASP 543,ASP-543,ASP543
	YM-543, a sodium-glucose transporter 2 (SGLT-2) inhibitor, is used potentially for the treatment of type 2 diabetes.
T70390	YM-543 choline
	YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and ...
T12436	PF-543 Citrate	Sphingosine Kinase 1 Inhibitor II Citrate	S1P Receptor
	PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).		S1P Receptor
T82354	GAD65 (524-543)
	GAD65 (524-543) is a biologically active peptide comprising amino acids 524 to 543 of glutamic acid decarboxylase 65 (GAD65). It represents an early islet antigen fragment that elicits proliferative T cell responses in t...
TP2452	Collagen type IV alpha1 (531-543)	Hep III peptide,Gefyfdlrlkgdk
	Collagen type IV alpha1 (531-543) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of type IV collagen and plays...
T68922	YM543 free base
	YM543 free base, a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor, effectively reduces blood glucose levels and is suitable for diabetes research.
T20954	Varlitinib Tosylate	Varlitinib-Tosylate,ARRY-334543 Tosylate,ARRY-543 Tosylate
	Varlitinib Tosylate is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2).
T70389	BMS986126
	BMS-986122 is a IRAK4 Inhibitor. BMS-986126 attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. BMS-986126 inhibited TLR7- and TLR9-dependent responses using cells derived from lupus pat...
T21919	UCF 101		Apoptosis
	UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.		Apoptosis
T6790	BMS-911543	BMS911543	Tyrosine Kinases , Histone Methyltransferase , JAK
	BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.		Tyrosine Kinases , Histone Methyltransferase , JAK
T22345	INCB054329	INCB-054329,INCB-54329,INCB-54329	Epigenetic Reader Domain
	INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2 with IC50 values of 44 nM, 5 nM, 9 nM, ...		Epigenetic Reader Domain
T23145	PHA 543613		Others , AChR
	PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.		Others , AChR
T22126	Org 25543 hydrochloride		GlyT
	Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptak...		GlyT
T77653	Z26395438		Sirtuin
	Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.		Sirtuin
T7610	GW284543	UNC10225170	MEK
	GW284543 (UNC10225170) is a selective inhibitor of MEK5 .		MEK
T5124	SRT 1720 dihydrochloride[925434-55-5(free base)]		Sirtuin
	SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).		Sirtuin
T2506	AZD-5438	AZD5438	CDK
	AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).		CDK