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SRT 1720 dihydrochloride[925434-55-5(free base)]

Catalog No. T5124 CAS T5124

SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).

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SRT 1720 dihydrochloride[925434-55-5(free base)], CAS T5124

Pack Size	Availability	Price/USD
1 mg	In stock	$ 56.00
2 mg	In stock	$ 77.00
5 mg	In stock	$ 108.00
10 mg	In stock	$ 173.00
25 mg	In stock	$ 295.00
50 mg	In stock	$ 471.00
100 mg	In stock	$ 688.00

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Purity: 98.43%

Biological Description

Chemical Properties

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Description	SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
Targets&IC50	SIRT1:0.16 μM (EC1.5), SIRT2:37 μM (EC1.5)

Molecular Weight	542.48
Formula	C25H25Cl2N7OS
CAS No.	T5124

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 80 mg/mL

H2O: 10 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6 2. Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan?,Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61 3. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122(6):2032-45. 4. Gao D, et al. Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity. Hypertension. 2016 Nov;68(5):1191-1199.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max Anti-Diabetic Compound Library Anti-Metabolism Disease Compound Library DNA Damage & Repair Compound Library Preclinical Compound Library Histone Modification Compound Library Epigenetics Compound Library

Related Products

Related compounds with same targets

SIRT2-IN-9 BML-278 WAY-323061 Z26395438 WAY-270360 MDL-800 MC3482 SIRT5 inhibitor 1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SRT 1720 dihydrochloride[925434-55-5(free base)] T5124 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin SRT 1720 dihydrochloride[925434555(free base)] SRT 1720 dihydrochloride[925434 55 5(free base)] inhibitor inhibit

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