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Catalog No. T6057Cas No. 1229582-33-5
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
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Pack SizePriceAvailabilityQuantity
5 mg$52In Stock
10 mg$79In Stock
25 mg$143In Stock
50 mg$233In Stock
100 mg$397In Stock
1 mL x 10 mM (in DMSO)$54In Stock
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Product Introduction

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
In vitro
URMC-099, administered intraperitoneally (i.p.) at a dosage of 10 mg/kg, demonstrates the ability to reduce the production of inflammatory cytokines within the body, protect neuronal structures, and alter the morphology and ultrastructural response of microglia to exposure to HIV-1 Tat. In mice, URMC-099 exhibits favorable pharmacokinetics and enhanced Central Nervous System (CNS) penetration. Additionally, URMC-099 significantly reduces the infiltration of neutrophils into the peritoneum of wild-type mice in response to fMLP.
In vivo
URMC-099 reduces chemotaxis in wild-type neutrophils induced by fMLP in vitro. Moreover, URMC-099 inhibits the release of TNFα in microglia triggered by lipopolysaccharides, as well as the release of cytokines in human monocytes stimulated by HIV-1 Tat. Additionally, URMC-099 prevents the destruction and phagocytosis of cultured neuronal axons by microglia.
Kinase Assay
HDAC IC50 Profiling: The in vitro inhibitory activity of compounds against seven human HDAC isoforms (1, 2, 4 C2A, 5 C2A, 6, 8, and 11) are performed with a fluorescent based assay according to the company's standard operating procedure. The IC50 values are determined using 10 different concentrations with 3-fold serial dilution starting at 10 μM. TSA and vorinostat are used as reference compounds.
Chemical Properties
Molecular Weight421.54
Cas No.1229582-33-5
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 6 mg/mL (14.2 mM)
DMSO: 75 mg/mL (177.9 mM)
Solution Preparation Table
1 mM2.3723 mL11.8613 mL23.7225 mL118.6127 mL
5 mM0.4745 mL2.3723 mL4.7445 mL23.7225 mL
10 mM0.2372 mL1.1861 mL2.3723 mL11.8613 mL
20 mM0.1186 mL0.5931 mL1.1861 mL5.9306 mL
50 mM0.0474 mL0.2372 mL0.4745 mL2.3723 mL
100 mM0.0237 mL0.1186 mL0.2372 mL1.1861 mL


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