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TargetMol | Compound Library

Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions. Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications). In this compound library, TargetMol collects 2154 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2620

Anti-Neurodegenerative Disease Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2154 compounds related to neurodegenerative diseases can be used for HTS or HCS;
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.;
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Dopamine Receptor
Adrenergic Receptor
GABA Receptor
Apoptosis
Autophagy
GluR
Cholinesterase (ChE)
Histamine Receptor
Opioid Receptor
Endogenous Metabolite
NMDAR
PDE
iGluR
Beta Amyloid
COX
MAO
Monoamine Oxidase
Gamma-secretase
JNK
Antibacterial
Serotonin Transporter
NF-κB
Reactive Oxygen Species
Norepinephrine
Potassium Channel
PPAR
Adenosine Receptor
GSK-3
Sodium Channel
Caspase
Calcium Channel
Cytochromes P450
Parasite
HIV Protease
Influenza Virus
CaMK
Nrf2
LRRK2
TNF
BACE
Mitophagy
CDK
ERK
Antifungal
Ferroptosis
Beta-Secretase
Cannabinoid Receptor
Mitochondrial Metabolism
Akt
Antibiotic
Dehydrogenase
IL Receptor
TRP/TRPV Channel
Bcr-Abl
Phosphatase
Transferase
NO Synthase
p38 MAPK
P-gp
Src
DNA/RNA Synthesis
Estrogen/progestogen Receptor
GlyT
Imidazoline Receptor
MMP
PI3K
Sigma receptor
Virus Protease
Antioxidant
Bcl-2 Family
FLT
Interleukin
IκB/IKK
Microtubule Associated
PARP
Phospholipase
ROS
Adenylyl Cyclase
AMPK
Aurora Kinase
c-Kit
Drug Metabolite
HDAC
Lipoxygenase
MEK
MRP
MT Receptor
OX Receptor
P2X Receptor
PKC
Sirtuin
VEGFR
Wnt/beta-catenin
AAK1
Anti-infection
Chloride channel
EGFR
FAAH
LPL Receptor
Melatonin Receptor
P2Y Receptor
PKA
S1P Receptor
SARS-CoV
ABC Transporter
Carbonic Anhydrase
CCR
Epigenetic Reader Domain
FGFR
Histone Methyltransferase
HMG-CoA Reductase
IGF-1R
JAK
mTOR
Neurokinin receptor
NOS
Prostaglandin Receptor
RAAS
Retinoid Receptor
ROR
Trk receptor
Tyrosinase
Amino Acids and Derivatives
Casein Kinase
c-Fms
Epoxide Hydrolase
Estrogen Receptor/ERR
Glucocorticoid Receptor
Glucosidase
HIF/HIF Prolyl-Hydroxylase
Histone Demethylase
HSV
MAPK
NADPH
NOD
p53
Rho
S6 Kinase
TGF-beta/Smad
Acyltransferase
Advanced Glycation End Products
Antifection
Antiviral
Aryl Hydrocarbon Receptor
ATM/ATR
CGRP Receptor
c-Met/HGFR
CRISPR/Cas9
CSF-1R
Cysteine Protease
Decarboxylase
DYRK
FAK
Free radical scavengers
FXR
Gap Junction Protein
GPCR
Guanylate cyclase
HBV
Histone Acetyltransferase
IFNAR
Immunology/Inflammation related
Integrin
Monoamine Transporter
NOD-like Receptor (NLR)
PAFR
PGE Synthase
Progesterone Receptor
Raf
Ras
Reverse Transcriptase
RSV
STAT
Stearoyl-CoA Desaturase (SCD)
STING
Topoisomerase
Transaminase
transporter
UGT
FOXO3
Adenosine Deaminase
Adiponectin Receptor
ALK
Androgen Receptor
Annexin A
Aromatase
Arrestin
ATPase
Bombesin Receptor
Chk
DNA Alkylation
DNA Methyltransferase
DUB
E1/E2/E3 Enzyme
GluCls
Glutaminyl Cyclase
Glutathione Peroxidase
GRK
GST
GTPase
Hck
HCN Channel
HCV Protease
Hexokinase
HIF
HSP
Hydroxylase
IAP
Indoleamine 2,3-Dioxygenase (IDO)
IRAK
LDL
Liver X Receptor
MLK
Monocarboxylate transporter
Na+/Ca2+ Exchanger
Neprilysin
Neuropeptide Y Receptor
NMU2R
NPC1L1
Nucleoside Antimetabolite/Analog
OAT
OCT
PAD
PAI-1
PAK
PDGFR
PDK
Proteasome
RANKL/RANK
RAR/RXR
ROCK
Serine/threonin kinase
SGK
SGLT
Somatostatin
Syk
Telomerase
Thrombin
TLR
BTK
Vitamin

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