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TargetMol | Compound Library

Anti-Neurodegenerative Disease Compound Library

Catalog No. L2620

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of specific neurons within the brains of affected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow significantly over the next few decades in the absence of any new therapeutic interventions.

Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications).

In this compound library, TargetMol collects 2154 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2620

Anti-Neurodegenerative Disease Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2154 compounds related to neurodegenerative diseases can be used for HTS or HCS;
  • Targets include AchE, NMDA, CGRP, β -secretase, γ -secretase, Dopamine receptor, Adenosine receptor, 5-HT receptor, etc.;
  • Some of them are FDA-approved;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Library Customization | TargetMol Library Composition

5-HT Receptor
AChR
Dopamine Receptor
Adrenergic Receptor
Apoptosis
Autophagy
GABA Receptor
iGluR
Endogenous Metabolite
GluR
Cholinesterase (ChE)
Histamine Receptor
Opioid Receptor
NMDAR
Beta Amyloid
PDE
ROS
Monoamine Oxidase
COX
Antibacterial
NF-κB
MAO
Serotonin Transporter
Reactive Oxygen Species
Potassium Channel
JNK
Parasite
Calcium Channel
PPAR
Gamma-secretase
Caspase
GSK-3
Norepinephrine
Sodium Channel
Adenosine Receptor
Cytochromes P450
TNF
Akt
ERK
Influenza Virus
Nrf2
HIV Protease
PI3K
Interleukin
CDK
CaMK
LRRK2
NO Synthase
p38 MAPK
Mitophagy
Ferroptosis
BACE
Beta-Secretase
Antifungal
Transferase
Drug Metabolite
Mitochondrial Metabolism
MMP
Virus Protease
Wnt/beta-catenin
DNA/RNA Synthesis
Sigma receptor
Antibiotic
Phosphatase
P-gp
Cannabinoid Receptor
Dehydrogenase
TRP/TRPV Channel
mTOR
Src
VEGFR
IL Receptor
SARS-CoV
Bcl-2 Family
IκB/IKK
Estrogen/progestogen Receptor
Bcr-Abl
PKC
Trk receptor
Sirtuin
AMPK
Phospholipase
Microtubule Associated
Imidazoline Receptor
Antioxidant
Melatonin Receptor
PARP
GlyT
Glucosidase
Lipoxygenase
HDAC
MEK
Anti-infection
Adenylyl Cyclase
Amino Acids and Derivatives
MRP
PKA
P2X Receptor
CCR
OX Receptor
glycosidase
EGFR
TLR
FLT
c-Kit
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
NOD-like Receptor (NLR)
Histone Methyltransferase
LPL Receptor
P2Y Receptor
Estrogen Receptor/ERR
MT Receptor
JAK
FAAH
Epigenetic Reader Domain
MAPK
Prostaglandin Receptor
Ras
S1P Receptor
GPCR
NOS
Carbonic Anhydrase
ROR
NADPH
Histone Demethylase
RAAS
AAK1
UGT
ABC Transporter
HSV
PTEN
Aurora Kinase
IGF-1R
TGF-beta/Smad
Retinoid Receptor
STAT
FGFR
MDM-2/p53
Neurokinin receptor
NOD
HMG-CoA Reductase
Chloride channel
Integrin
c-Met/HGFR
IFNAR
PERK
HBV
Rho
FXR
Aryl Hydrocarbon Receptor
Glucocorticoid Receptor
AAK1 (AP2 associated kinase 1)
Monoamine Transporter
Angiotensin-converting Enzyme (ACE)
Epoxide Hydrolase
PGE Synthase
Antiviral
Histone Acetyltransferase
transporter
Casein Kinase
c-Fms
IRAK
S6 Kinase
p53
Advanced Glycation End Products
ATPase
Transaminase
Monocarboxylate transporter
DYRK
Necroptosis
MIF
Progesterone Receptor
OCT
Serine/threonin kinase
Nucleoside Antimetabolite/Analog
Cysteine Protease
Liver X Receptor
CSF-1R
IAP
Immunology/Inflammation related
Topoisomerase
PAFR
Raf
GRK
Antifection
Guanylate cyclase
PDGFR
Stearoyl-CoA Desaturase (SCD)
DUB
OXPHOS
Acyltransferase
HSP
STING
Free radical scavengers
Decarboxylase
RSV
ATM/ATR
Reverse Transcriptase
CRISPR/Cas9
Hydroxylase
FOXO
CGRP Receptor
Gap Junction Protein
FAK
CFTR
FOXO3
Thyroid hormone receptor(THR)
Proteasome
Taste receptor
CAT
NPC1L1
RAR/RXR
HCV Protease
Glutaminyl Cyclase
Reductase
Na+/Ca2+ Exchanger
Arrestin
Lipase
Glutathione Peroxidase
GTPase
c-Myc
CaSR
Serine Protease
Hck
Neurotensin Receptor
Glutaminase
LDLR
ROCK
NR4A
RANKL/RANK
IDO
Prolyl Endopeptidase (PREP)
Annexin A
E1/E2/E3 Enzyme
RIP kinase
Adiponectin Receptor
LDL
Hexokinase
HCN Channel
Neuropeptide Y Receptor
DNA Alkylation
Bombesin Receptor
PAK
Somatostatin
Chk
PAD
Cadherin
Orphan Receptor
Indoleamine 2,3-Dioxygenase (IDO)
Androgen Receptor
Telomerase
SGLT
ATP Citrate Lyase
Lipid
PSMA
Survivin
OAT
MNK
GluCls
PAI-1
Pyroptosis
ALK
Neprilysin
GST
Carboxypeptidase
FKBP
Aromatase
PDK
Aquaporin
HIF
Adenosine Deaminase
Cuproptosis
SGK
REV-ERB
Syk
DNA Methyltransferase
Thrombin
Liposome
ROS Kinase
MLK
Vitamin
BTK
NMU2R
NMUR

Keywords