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Syrosingopine

Catalog No. TN2252   CAS 84-36-6

Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.

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Syrosingopine Chemical Structure
Syrosingopine, CAS 84-36-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 61.00
5 mg In stock $ 145.00
10 mg In stock $ 223.00
25 mg In stock $ 381.00
50 mg In stock $ 572.00
100 mg In stock $ 789.00
1 mL * 10 mM (in DMSO) In stock $ 213.00
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Purity: 99.78%
Purity: 99.6%
Purity: 99.25%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.
In vitro The anticancer activity of the widely used diabetic drug metformin is strongly potentiated by Syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to Syrosingopine??s known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine binds to the glycolytic enzyme α±-enolase in vitro, and the expression of the γ-enolase isoform correlates with nonresponsiveness to the drug combination. Syrosingopine sensitized cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound[1]
Source
Molecular Weight 666.71
Formula C35H42N2O11
CAS No. 84-36-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.5 mg/mL (93.74 mM), sonification is recommended.

TargetMolReferences and Literature

1. Syrosingopine sensitizes cancer cells to killing by metforminSci. Adv.,2016 Dec; 2(12): e1601756.

TargetMolCitations

1. Tian L R, Lin M Z, Zhong H H, et al. Nanodrug regulates lactic acid metabolism to reprogram the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy. Biomaterials Science. 2022

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Neurodegenerative Disease Compound Library ReFRAME Related Library Inhibitor Library Bioactive Compound Library Orally Active Compound Library Anti-Cancer Compound Library Human Metabolite Library Bioactive Compounds Library Max Natural Product Library

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Related compounds with same targets
A-77636 Eticlopride hydrochloride CLOZAPINE N-OXIDE ABT-724 Promethazine Flunarizine dihydrochloride D3R/MOR antagonist 1 D4R agonist-1

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Keywords

Syrosingopine 84-36-6 GPCR/G Protein Neuroscience Dopamine Receptor cancer NAD+ Su-3118 MCTs Su 3118 synthetic lethality inhibit metformin lactate glycolysis Su3118 Monocarboxylate Transporter Inhibitor inhibitor

 

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