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Hederacolchiside A1

Catalog No. T2P2806   CAS 106577-39-3
Synonyms: Raddeanoside R13

Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacolchiside A1 shows antiproliferation activities in three cancer cell lines with the IC50 value of 2.4 uM, it exhibits a preferential cytotoxicity on a pigmented melanoma cell line. It suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway.

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Hederacolchiside A1 Chemical Structure
Hederacolchiside A1, CAS 106577-39-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 71.00
5 mg In stock $ 165.00
10 mg In stock $ 246.00
25 mg In stock $ 413.00
50 mg In stock $ 613.00
100 mg In stock $ 873.00
1 mL * 10 mM (in DMSO) In stock $ 278.00
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Purity: 99.92%
Purity: 99.54%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacolchiside A1 shows antiproliferation activities in three cancer cell lines with the IC50 value of 2.4 uM, it exhibits a preferential cytotoxicity on a pigmented melanoma cell line. It suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway.
Source
Synonyms Raddeanoside R13
Molecular Weight 897.1
Formula C47H76O16
CAS No. 106577-39-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.3 mg/mL (92.89 mM ), Sonication is recommended.

TargetMolReferences and Literature

1. Wang L , Wang Z , Su S , et al. Synthesis and cytotoxicity of oleanolic acid trisaccharide saponins[J]. Carbohydrate Research, 2017, 442:9-16. 2. Barthomeuf C , Boivin D , Richard Béliveau. Inhibition of HUVEC tubulogenesis by hederacolchiside-A1 is associated with plasma membrane cholesterol sequestration and activation of the Ha-Ras/MEK/ERK cascade[J]. Cancer Chemotherapy & Pharmacology, 2004, 54(5):432-440. 3. Delmas F, Giorgio C D , Elias R , et al. Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro.[J]. Planta Medica, 2000, 66(04):343-347.

Related compound libraries

This product is contained In the following compound libraries:
Kinase Inhibitor Library Natural Product Library Antiparasitic Natural Product Library Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Anti-Parasitic Compound Library Natural Product Library for HTS Reprogramming Compound Library Anti-Obesity Compound Library Anti-Cancer Compound Library

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Keywords

Hederacolchiside A1 106577-39-3 Apoptosis Cytoskeletal Signaling MAPK Microbiology/Virology PI3K/Akt/mTOR signaling mTOR Parasite PI3K ERK MEK Akt Mammalian target of Rapamycin Phosphoinositide 3-kinase Inhibitor PKB inhibit Protein kinase B Hederacolchiside A 1 Hederacolchiside A-1 Raddeanoside R13 inhibitor

 

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